Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1415
Título : Analysis of gene rearrangements using a fluorescence in situ hybridization method in Mexican patients with acute lymphoblastic leukemia: experience at a single institution
Creador: Perez Vera, Patricia
Nivel de acceso: Open access
Palabras clave : Niño
Preescolar
Aberraciones Cromosómicas
Cromosomas Humanos Par 1
Cromosomas Humanos Par 11
Cromosomas Humanos Par 19
Cromosomas Humanos Par 22
Cromosomas Humanos Par 9
Subunidad alfa 2 del Factor de Unión al Sitio Principal - genética
Humanos
Hibridación Fluorescente in Situ- métodos
México
Proteína de la Leucemia Mieloide-Linfoide - genética
Proteínas de Fusión Oncogénicas
Leucemia-Linfoma Linfoblástico de Células Precursoras - genética
Child
Child, Preschool
Chromosome Aberrations
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 19
Chromosomes, Human, Pair 22
Chromosomes, Human, Pair 9
Core Binding Factor Alpha 2 Subunit - genetics
Humans
In Situ Hybridization, Fluorescence - methods
Mexico
Myeloid-Lymphoid Leukemia Protein - genetics
Oncogene Proteins, Fusion- genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Leucemia Linfocítica Aguda
genética
Hibridización in Situ Fluorescente
Cromosomas Humanos
Análisis Citogenético
Acute Lymphoid Leukemia
genetics
In Situ Hybridization, Fluorescence
Chromosomes, Human
Cytogenetic Analysis
Descripción : We evaluated the prevalence of BCR/ABL, MLL, and ETV6/RUNX1 rearrangements as well as CDKN2A (alias p16) deletion in a group of Mexican children with acute lymphoblastic leukemia (ALL) to determine whether the changes coexist, and to compare the incidences found with other reports in the literature. To increase the detection of these abnormalities, we combined conventional cytogenetics and fluorescence in situ hybridization (FISH) analysis. Bone marrow samples were obtained from 59 consecutive children with ALL. FISH detected a total of 63 abnormalities with the selected probes, 34 of which were related to the conventional cytogenetic results. The most common abnormality was the p16 deletion (22.8%), followed by MLL and ETV6/RUNX1 rearrangements (8.7%), and the BCR/ABL fusion was the least frequent (2.7%). The coexistence of two recurrent abnormalities with specific prognostic significance in the same patient was not found. A lesser proportion of the p16 deletion in T-ALL patients was observed, probably related to the low prevalence of this subtype in our population. In addition, we confirmed the low frequency of the ETV6/RUNX1 fusion observed in Hispanics. Due to the different prevalence of these abnormalities in the Mexican population, similar studies should be conducted analyzing new rearrangements, to improve the adequate classification of the abnormalities and the stratification in prognostic groups. © 2008 Elsevier Inc. All rights reserved.
Colaborador(es) u otros Autores: Salas C.
Montero-Ruiz O.
Frías S.
Dehesa G.
Jarquín B.
Rivera-Luna R.
Fecha de publicación : 2008
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1016/j.cancergencyto.2008.04.003
Fuente: Cancer Genetics and Cytogenetics 184(2):94 - 98
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1415
Idioma: eng
Aparece en las colecciones: Artículos

Ficheros en este ítem:
No hay ficheros asociados a este ítem.


Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.