Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1593
Título : Antihelmínticos como factor de riesgo en la obstrucción intestinal por Ascaris lumbricoides en niños
Anthelmintics as a risk factor in intestinal obstruction by Ascaris lumbricoides in children
Creador: Vásquez Tsuji O.,
Nivel de acceso: Open access
Palabras clave : Adolescente
Albendazol - Efectos adversos
Albendazol - uso terapéutico
Animales
Antihelmínticos - Efectos adversos
Antihelmínticos - uso terapéutico
Ascariasis - complicaciones
Ascariasis - tratamiento farmacológico
Ascaris lumbricoides
Estudios de Casos y Controles
Distribución de Chi-Cuadrado
Niño
Preescolar
Femenino
Humanos
Lactante
Obstrucción Intestinal - inducido químicamente
Obstrucción Intestinal - parasitología
Modelos Logísticos
Masculino
Mebendazol - Efectos adversos
Mebendazol - uso terapéutico
Oportunidad Relativa
Estudios Retrospectivos
Factores de Riesgo
Adolescent
Albendazole - adverse effects
Albendazole - therapeutic use
Animals
Anthelmintics - adverse effects
Anthelmintics - therapeutic use
Ascariasis - complications
Ascariasis - drug therapy
Ascaris lumbricoides
Case-Control Studies
Chi-Square Distribution
Child
Child, Preschool
Female
Humans
Infant
Intestinal Obstruction - chemically induced
Intestinal Obstruction - parasitology
Logistic Models
Male
Mebendazole - adverse effects
Mebendazole - therapeutic use
Odds Ratio
Retrospective Studies
Risk Factors
Vermifugos
Factores de Riesgo
Obstrucción Intestinal
Ascariasis
Anthelmintics
Risk Factors
Intestinal Obstruction
Ascariasis
Descripción : In a retrospective study the authors analyzed the clinical records of 199 children ages one month to 16 years hospitalized, with the diagnosis of intestinal ascariasis, in the Instituto Nacional de Pediatria of Mexico from 1984 to 1999. The purpose of the study was to evaluate the use of anthelmintics drugs as a risk factor of intestinal obstruction by A. lumbricoides. Two groups were made for the study: Group A (n = 66) of children who presented intestinal obstruction, Group B (n = 133) children with no complications. A comparative analysis of clinical data of both groups was made by means of chi square with Yates correction and a stratified analysis by means of chi square. Possible confusing elements were overcrowding, age and the use of antiparasitic drugs. The calculus of risk factors for intestinal obstruction by A. lumbricoides was done by means of contingency tables of 2 x 2 and odds ratio with an IC of 95%. The significant risk factors were included in a model of logistics regression with an impact variable consting in the presence or absence of intestinal obstruction in order to establish a multivariate model of predictive risk at level of significance of p < 0.05. Twenty-seven patients (40.90%) in group A (n = 66) were given anthelmintics medications prior to the intestinal obstruction: mebendazol, 14 (51-85%); two, albedazol (7.4%); eight, a non-specified anthelmintic (29.6%). In addition, an anthelmintic medication without a specified time of ingestion: two with mebendazol and one with piperazine (11.3%). In the case of mebendazol, the drug most frequently associated with intestinal obstruction, seven patients received it on the same day of the obstruction; five patients received it between one and seven days prior to the obstruction; two received it seven days prior to the complication. In the control group, only 7% had taken the anthelmintic one to seven days before the diagnosis of uncomplicated intestinal ascariasis diagnosis was made. With the step by step (Backward) logistic regression conditioned by the treatment variable with an anthelmintic, an X2 = 38.15 gl, p < 0.000 was obtained for which reason it was considered by A. lumbricoides. Of the probable risk factors analyzed in this study, the only one capable of influencing and predicting the presentation of intestinal obstruction by A. lumbricoides in children, was the prior anthelmintic treatment particularly with mebendazol.
Colaborador(es) u otros Autores: Gutiérrez Castrellón P.
Yamazaki Nakashimada M.A.
Arredondo Suárez J.C.
Campos Riveral T.
Martínez Barbosa I.
Fecha de publicación : 2000
Tipo de publicación: Artículo
Formato: pdf
Fuente: Boletin Chileno de Parasitologia 55(1-2):3 - 7
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1593
Idioma: spa
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