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Título : Anti-cardiolipin, anti-cardiolipin plus bovine, or human beta(2)glycoprotein-I and anti-human beta(2)glycoprotein-I antibodies in a healthy infant population
Creador: Cabiedes J.,
Nivel de acceso: Open access
Palabras clave : Adulto
Animales
Anticuerpos Anticardiolipina - sangre
Autoanticuerpos - sangre
Autoanticuerpos - inmunología
Bovinos
Niño
Preescolar
Ensayo de Inmunoadsorción Enzimática
Glicoproteínas - inmunología
Humanos
Inmunoglobulina A - sangre
Inmunoglobulina A - inmunología
Inmunoglobulina G - sangre
Inmunoglobulina G - inmunología
Inmunoglobulina M - sangre
Inmunoglobulina M - inmunología
Lactante
Masculino
México
Valores de Referencia
beta 2 Glicoproteína I
Adult
Animals
Antibodies, Anticardiolipin - blood
Autoantibodies - blood
Autoantibodies - immunology
Cattle
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Glycoproteins - immunology
Humans
Immunoglobulin A - blood
Immunoglobulin A - immunology
Immunoglobulin G - blood
Immunoglobulin G - immunology
Immunoglobulin M - blood
Immunoglobulin M - immunology
Infant
Male
Mexico
Reference Values
beta 2-Glycoprotein I
True anticardiolipin antibodies
Anti-β2GP-I antibodies
ELISA
Healthy Mexican children
Descripción : Background. Pathogenic antiphospholipid antibodies studies are usually conducted on populations of adults. Studies involving normal children are scant. Methods. Antibody reactivity against CL alone (true aCL), CL-complexed to bovine β2GP-I (aCL-bovine β2GP-I), or human (aCL-human β2GP-I) β2GP-I, or to phospholipid-free human β2GP-I (anti-human β2GP-I) was determined by ELISA in serum samples from 360 Mexican children ranging from 1 month through 8 years of age. Results. Statistical analysis of variance and rankings of Kruskal-Wallis demonstrated no significant difference in all tested antibody activities between ages and genders of the study population. Values are presented as a percentile distribution included between 5 and 99, corresponding to the percentages of the studied population. Normal arbitrary units (AU) for IgG, IgA, and IgM true aCL that correspond to the 95 and 99 percentiles are as follows: 2.15 and 3.5; 2.35 and 5.0, and 3.15 and 4.5, respectively. IgG, IgA, and IgM aCL-bovine β2GP-I activities are 2.6 and 5.0, 3.0 and 5.0, and 2.7 and 6.0 AU, respectively, while IgG activities of aCL-bovine and human β2GP-I are 1.45 and 1.80, respectively. Normal values for IgG anti-human β2GP-I are 1.85 AU. Conclusions. While elevated serum levels of antibodies to CL and/or β2GP-I have been associated with thrombotic and hematologic manifestations, the majority of reports deal with adult populations. We report the cut-off values (in AU, international PL units, and international units for β2GP-I) of the specific serologic response of true aCL, aCL-bovine β2GP-I, aCL-human β2GP-I, and anti-human β2GP-I in healthy Mexican children. © 2002 IMSS. Published by Elsevier Science Inc.
Colaborador(es) u otros Autores: Trejo-Hernández J.
Loredo-Abdala A.
Castilla-Serna L.
López-Mendoza A.T.
Cordero-Esperón H.A.
Huerta M.T.
Cabral A.R.
Alarcón-Segovia D.
Fecha de publicación : 2002
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1016/S0188-4409(01)00359-9
Fuente: Archives of Medical Research 33(2):175 - 179
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1626
Idioma: eng
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