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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1648| Título : | Antidepressant-like and toxicological effects of a standardized aqueous extract of Chrysactinia mexicana A. Gray (Asteraceae) in mice |
| Creador: | Cassani Julia |
| Nivel de acceso: | Open access |
| Palabras clave : | Animales Antidepresivos - análisis Antidepresivos - farmacología Antidepresivos - toxicidad Asteraceae Conducta Animal - Efectos de drogas Flavonoides - análisis Flavonoides - farmacología Flavonoides - toxicidad Suspensión Trasera Dosificación Letal Mediana Masculino Ratones Actividad Motora - Efectos de drogas Fuerza Muscular - Efectos de drogas Fitoquímicos - análisis Fitoquímicos - farmacología Fitoquímicos - toxicidad Componentes Aéreos de las Plantas Extractos Vegetales - análisis Extractos Vegetales - farmacología | Extractos Vegetales - toxicidad Desempeño Psicomotor - Efectos de drogas Prueba de Desempeño de Rotación con Aceleración Constante Animals Antidepressive Agents - analysis Antidepressive Agents - pharmacology Antidepressive Agents - toxicity Asteraceae Behavior, Animal - drug effects Flavonoids - analysis Flavonoids - pharmacology Flavonoids - toxicity Hindlimb Suspension Lethal Dose 50 Male Mice Motor Activity - drug effects Muscle Strength - drug effects Phytochemicals - analysis Phytochemicals - pharmacology Phytochemicals - toxicity Plant Components, Aerial Plant Extracts - analysis Plant Extracts - pharmacology Plant Extracts - toxicity Psychomotor Performance - drug effects Rotarod Performance Test Chrysactinia Mexicana Damiana falso Damianita Depresión Toxicidad Chrysactinia Mexicana Damiana false Damianita Depression Toxicity |
| Descripción : | Ethnopharmacological relevance C. mexicana A. Gray (Asteraceae) is a native of North America plant. In Mexico's folk medicine it is used for the fever, rheumatism and as a diuretic, antispasmodic, general tonic or adaptogenic herb, and as a stimulant agent. The aim of the study was to examine the antidepressant-like properties of an aqueous extract of C. mexicana (Cm), in order to scientifically describe its potential value in the management of depressive disorders. To evaluate the acute and subacute toxic effects of Cm and effects on hepatic and biochemical functions in mice. Materials and methods Antidepressant-like effects of Cm were evaluated in the Forced swimming and suspension tail tests (FST and TST), the ambulatory activity was measure in the Open Field Test (OFT), motor coordination was evaluated in the inverted screen and gyratory roller (IST and Rota-rod), the biochemical and histopathological analysis were carried out. Phytochemical studies of organic and aqueous extracts of Cm were thoroughly conducted. Results Cm produced a significant reduction of the immobility time both FST and in TST, without affect the ambulatory activity of experimental mice. Cm did not produce any damage in the hepatic functions, nor produce any significant change in the morphological tissue of organs examined. Conclusions Chrysactinia mexicana induces a clear antidepressant-like effect in mice, without affect any basic functions. The consumption of this medicinal plant does not represent risk for health. The chemical analysis showed the flavonoids free and glycosides mainly. © 2015 Elsevier Ireland Ltd. All rights reserved. |
| Colaborador(es) u otros Autores: | Ferreyra-Cruz Octavio Alberto Dorantes-Barrón Ana María Vigueras Villaseñor Rosa María Arrieta-Baez Daniel Estrada-Reyes Rosa |
| Fecha de publicación : | 2015 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1016/j.jep.2015.05.055 |
| Fuente: | Journal of Ethnopharmacology 171():295 - 306 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1648 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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