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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1692| Título : | A case of cervical cancer expressed three mRNA variant of Hyaluronan-mediated motility receptor |
| Creador: | Villegas Ruiz, Vanessa |
| Nivel de acceso: | Open access |
| Palabras clave : | Empalme Alternativo Antígenos CD44 - genética Antígenos CD44 - metabolismo Secuencia de Bases Exones Proteínas de la Matriz Extracelular - genética Proteínas de la Matriz Extracelular - metabolismo Regulación Neoplásica de la Expresión Génica Variación Genética Células HeLa Datos de Secuencia Molecular ARN Mensajero - genética Reacción en Cadena de la Polimerasa de Transcriptasa Inversa Análisis de Secuencia de ADN Transfección Neoplasias del Cuello Uterino - genética Neoplasias del Cuello Uterino - metabolismo Neoplasias del Cuello Uterino - patología Alternative Splicing Antigens, CD44 - genetics Antigens, CD44 - metabolism Base Sequence Exons Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Gene Expression Regulation, Neoplastic Genetic Variation HeLa Cells Molecular Sequence Data RNA, Messenger - genetics Reverse Transcriptase Polymerase Chain Reaction Sequence Analysis, DNA Transfection Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology Cervical cancer, alternative splicing, HMMR, expression |
| Descripción : | Cervical cancer is the second malignancy in Mexico, little is known about the prognostic factors associated with this disease. Several cellular components are important in their transformation and progression. Alternative mRNA splice is an important mechanism for generating protein diversity, nevertheless, in cancer unknown mRNA diversity is expressed. Hyaluronan-mediated motility receptor (HMMR, RHAMM, CD168) is a family member of proteins, hyaluronan acid dependent, and has been associated with different malignant processes such as: angiogenesis, cell invasiveness, proliferation, metastasis and poor outcome in some tumors. In the present study we identified expression of HMMR in cervical cancer by means of RT-PCR and sequencing. Our results indicate co-expression of two HMMR variants in all samples, and one case expressed three alternative HMMR splice transcripts. These results showed the heterogeneity of mRNA transcripts of HMMR that could express in cancer and the expression of HMMR could be marker of malignancy in CC. |
| Colaborador(es) u otros Autores: | Salcedo M. Zentella-Dehesa A. Montes de Oca E.V. Román-Basaure E. Mantilla-Morales A. Dávila-Borja V.M. Juárez-Méndez S. |
| Fecha de publicación : | 2014 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Fuente: | International Journal of Clinical and Experimental Pathology 7(5):2256 - 2264 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1692 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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