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Título : Antioxidant capacity of "mexican arnica" heterotheca inuloides cass natural products and some derivatives: Their anti-inflammatory evaluation and effect on C. elegans life span
Creador: Rodríguez Chávez, José Luis
Nivel de acceso: Open access
Palabras clave : Animales
Antiinflamatorios - química
Antiinflamatorios - aislamiento & purificación
Antiinflamatorios - farmacología
Antioxidantes - química
Antioxidantes - metabolismo
Asteraceae - química
Asteraceae - metabolismo
Productos Biológicos - química
Productos Biológicos - aislamiento & purificación
Productos Biológicos - farmacología
Caenorhabditis elegans - fisiología
Depuradores de Radicales Libres - química
Peroxidación de Lípido - efectos de drogas
Longevidad - efectos de drogas
Extractos Vegetales - química
Especies Reactivas de Oxígeno - química
Especies Reactivas de Oxígeno - metabolismo
Superóxidos - química
Animals
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - isolation & purification
Anti-Inflammatory Agents - pharmacology
Antioxidants - chemistry
Antioxidants - metabolism
Asteraceae - chemistry
Asteraceae - metabolism
Biological Products - chemistry
Biological Products - isolation & purification
Biological Products - pharmacology
Caenorhabditis elegans - physiology
Free Radical Scavengers - chemistry
Lipid Peroxidation - drug effects
Longevity - drug effects
Plant Extracts - chemistry
Reactive Oxygen Species - chemistry
Reactive Oxygen Species - metabolism
Superoxides - chemistry-
Antiinflamatorios
Antioxidantes
Asteraceae
Caenorhabditis elegans
Anti-Inflammatory Agents
Antioxidants
Asteraceae
Caenorhabditis elegans
Descripción : It has been suggested that the accumulation of biomolecular damage caused by reactive oxygen species (ROS) contributes to aging. The antioxidant activity is related to the ability of certain compounds to protect against the potentially harmful effect of processes or reactions involving ROS. This ability is associated with the termination of free radical propagation in biological systems. From Heterotheca inuloides various compounds which have shown to possess antioxidant capacity and scavenging ROS. The aim of this study was to determine the antioxidant capacity of additional natural components isolated from H. inuloides and some semisynthetic derivatives, their anti-inflammatory activity and the effect on Caenorhabditis elegans nematode life span. Compounds showed ability to inhibit various biological processes such as lipid peroxidation, scavenge nonbiological important oxidants such as 1O2, OH, H2O2, and HOCl and scavenge non biological stable free radicals (DPPH). Some cadinane type compounds showed possess antioxidant, ROS scavenging capacity, anti-inflammatory activity, and effect on the C. elegans life span. Flavonoid type compounds increased the life of the nematode and quercetin was identified as the compound with the greatest activity. The modification of chemical structure led to a change in the antioxidant capacity, the anti-inflammatory activity, and the survival of the worm. © 2015 José Luis Rodríguez-Chávez et al.
Colaborador(es) u otros Autores: Coballase-Urrutia E
Nieto-Camacho A
Delgado-Lamas G.
Fecha de publicación : 2015
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1155/2015/843237
Fuente: Oxidative Medicine and Cellular Longevity 2015():1-11
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1726
Idioma: eng
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