Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1748
Título : Antioxidant effects of selenium in rat brain and the stimulating role of nitric oxide
Creador: Guzman, David C
Nivel de acceso: Open access
Palabras clave : Antioxidantes - farmacología
Encéfalo - enzimología
Oxido nítrico - fisiología
Selenio - Farmacología
ATPasa Intercambiadora de Sodio-Potasio
Antioxidants - pharmacology
Brain - enzymology
Nitric Oxide - physiology
Selenium - pharmacology
Sodium-Potassium-Exchanging ATPase - metabolism
Selenio
Regiones del cerebro
Peroxidación de lípido
Na
K ATPasa
Selenium
Brain regions
Lipid peroxidation
Na
K ATPase
Descripción : OBJECTIVE: To evaluate the antioxidant effect of selenium on Na+, K(+)-ATPase in rat brain in the presence of nitric oxide. METHODS: Male Wistar rats (70 g) were treated as follows: group 1 received 1 microg of i.p. sodium nitroprus-side per kg (SNP), group 2 received 5 microg sodium selenite during 20 days, group 3 received sodium selenite 5 microg + SNP 1 microg and the control group received vehicle 50 microl (0.9% NaCl), same period and route. At the end of treatment, animals were sacrificed and their brain dissected into cortex, hemispheres, cerebellum and brain stem in order to determine lipid peroxidation (TBARS), Na+, K+ ATPase and total ATPase in each section. Blood hemoglobin concentration (Hb) and prostate weight were also assessed. RESULTS: A significant increase of Hb in blood and of proteins in cortex and hemisphere was detected, but TBARS values fell due to the effect of sodium selenite in all examined regions, except for cerebellum. ATPase activity declined in all groups and regions with and without NTP. We conclude that diet supplementary selenium to inhibit NO generation can be a useful treatment in chronic inflammatory diseases.
Colaborador(es) u otros Autores: Ruiz NL
 Mejía GB
 García EH
 Vázquez IR
 Del Angel DS
 Ramírez AM
 Juárez Olguín H
Fecha de publicación : 2003
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1080/1028415031000104181
Fuente: Nutritional Neuroscience 6(3):177 - 182
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1748
Idioma: eng
Aparece en las colecciones: Artículos

Ficheros en este ítem:
No hay ficheros asociados a este ítem.


Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.