Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1915
Título : Assessment of oxidative damage induced by acute doses of morphine sulfate in postnatal and adult rat brain
Creador: Calderón Guzmán, David
Nivel de acceso: Open access
Palabras clave : Factores de edad - animales
Cerebro - efecto de drogas - Ratas
Cerebro - metabolismo - Ratas
Relación Dosis-Respuesta a Droga - Ratas
glutatión - metabolismo - Ratas
Morfina - farmacología - Ratas
Morfina - metabolismo - Ratas
Morfina - uso terapéutico - Ratas
Narcóticos - farmacología - Ratas
Estrés oxidativo - efecto de drogas - Ratas
Ratas Sprague-Dawley - Ratas
Ratas Wistar - Ratas
Serotonina - metabolismo - Ratas
ATPasa Intercambiadora de Sodio-Potasio - metabolismo - Ratas
Age Factors - animals
Brain - drug effects - Rats
Brain - metabolism - Rats
Dose-Response Relationship, Drug - Rats
Glutathione - metabolism - Rats
Morphine - pharmacology - Rats, Morphine -metabolism - Rats
Morphine - therapeutic use - Rats
Narcotics - pharmacology - Rats, Oxidative Stress - drug effects - Rats
Rats, Sprague-Dawley - Rats
Rats, Wistar - Rats
Serotonin - metabolism - Rats
Sodium-Potassium-Exchanging ATPase -metabolism - Rats
Daño cerebral
Radicales libres
Glutatión
Morfina
Daño oxidativo
Opioides
Brain damage
Free radicals
Glutathione
Morphine
Oxidative damage
Opioids
Descripción : The aim of the present study is to evaluate the oxidative damage in rats of different ages. Weaned rats of 25 g and adults of 300 g were used in groups of 6, a single i.p. dose of morphine sulfate of 3, 6 or 12 mg/kg was administered. All animals were sacrificed to measure GSH and 5-HT levels in brain by liquid chromatography, as well as Na+, K+-ATPase and total ATPase enzymatic activity. 5-HT levels decreased significantly (p<0.05) in adult animals that received 3 and 6 mg morphine. Na+, K+-ATPase activity increased significantly (p<0.05) in all groups of weaned animals. In adult animals, Na+, K+-ATPase and total ATPase partially diminished. GSH levels diminished significantly (p<0.05) both in weaned and in adult groups. The results indicate age-induced changes in cellular regulation and biochemical responses to oxidative stress induced by morphine.
Colaborador(es) u otros Autores: Espitia Vazquez I
Osnaya Brizuela N
Garcia Alvarez R
Barragan Mejia G
Hernandez Garcia E
Santamaria D
De La Rosa De Apreza M
Juarez Olguin H
Fecha de publicación : 2006
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1007/s11064-006-9053-7
Fuente: Neurochemical Research 31(4):549 - 554
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1915
Idioma: eng
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