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Título : Association between two polymorphisms of histamine-metabolising enzymes and the severity of allergic rhinitis in a group of Mexican children
Creador: Meza Velázquez, MR
Nivel de acceso: Open access
Palabras clave : Amina Oxidasa (conteniendo Cobre) - genética
Niño
Preescolar
Análisis Mutacional de ADN
Progresión de la Enfermedad
Femenino
Frecuencia de los Genes
Estudios de Asociación Genética
Predisposición Genética a la Enfermedad
Genotipo
Histamina - sangre
Histamina N-Metiltransferasa - genética
Humanos
Inmunoglobulina E - sangre
Masculino
México
Polimorfismo de Nucleótido Simple
Rinitis Alérgica - genética
Amine Oxidase (Copper-Containing) - genetics
Child
Child, Preschool
DNA Mutational Analysis
Disease Progression
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Histamine - blood
Histamine N-Methyltransferase - genetics
Humans
Immunoglobulin E - blood
Male
Mexico
Polymorphism, Single Nucleotide
Rhinitis, Allergic - genetics
Rinitis Alérgica
Histaminasa
Histamina
Histamina Metiltransferasa
Polimorfismo
Allergic rhinitis; Diamine oxidase; Histamine; Histamine N-methyl transferase; Polymorphisms
Descripción : Background: It has been suggested that polymorphisms of histamine metabolising enzymes can be a risk factor for developing histamine-involving diseases. The aim of the present study is to research the possible association between two functional single nucleotide polymorphisms (SNPs): C314T in the Histamine-N-Methyl Transferase gene and C2029G in the Diamine Oxidase gene, with the severity of allergic rhinitis and the number of allergic diseases, in a group of allergic Mexican children. Methods: We studied 154 unrelated allergic children. SNPs were analysed by RT-PCR. The total serum IgE was measured by chemiluminescence and the serum histamine by ELISA. We used logistic regression analysis to determine OR. Results: Patients carrying the mutant allele for any SNP had more risk to develop higher rhinitis severity or a bigger number of allergic diseases. Haplotype analysis revealed that this effect is synergistic. In patients carrying one or two mutant alleles, serum histamine levels were higher than those of patients carrying only wild alleles. Serum IgE levels were not associated with the presence of mutant alleles. Conclusion: The presence of these SNPs in patients with allergic rhinitis can lead to higher serum histamine, therefore to a higher risk of developing more severe symptoms or more associated allergic diseases, even if the serum IgE remains low. © 2016 SEICAP.
Colaborador(es) u otros Autores: López-Márquez F.
Espinosa-Padilla S.
Rivera-Guillen M.
Gutíerrez-Díaz N.
Pérez-Armendáriz L.
Rosales-González M.
Fecha de publicación : 2015
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1016/j.aller.2016.01.002
Fuente: Allergologia et Immunopathologia 44(5):433-438
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1970
Idioma: eng
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