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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2106| Título : | BCR-ABL, ETV6-RUNX1 and E2A-PBX1: Prevalence of the most common acute lymphoblastic leukemia fusion genes in Mexican patients |
| Creador: | Jimínez Morales S., |
| Nivel de acceso: | Open access |
| Palabras clave : | Adolescente Niño Preescolar Subunidad alfa 2 del Factor de Unión al Sitio Principal - genética Femenino Proteínas de Fusión bcr-abl - genética Leucemia-Linfoma Linfoblástico de Células T Precursoras - etnología Leucemia-Linfoma Linfoblástico de Células T Precursoras - genética Proteínas Proto-Oncogénicas c-ets - genética Proteínas Represoras - genética Adolescent Child Child, Preschool Core Binding Factor Alpha 2 Subunit - genetics Female Fusion Proteins, bcr-abl - genetics Gene Frequency Homeodomain Proteins - genetics Humans Infant Male Mexico Oncogene Proteins, Fusion - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - ethnology Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Proto-Oncogene Proteins c-ets - genetics Repressor Proteins - genetics Acute lymphoblastic leukemia (ALL) BCR-ABL E2A-PBX1 fusion genes ETV6-RUNX1 Mexican pediatric patients |
| Descripción : | This study was conducted to determine the frequency of the most common fusion genes in Mexican pediatric patients with acute lymphoblastic leukemia (ALL). Molecular analysis using RT-PCR was carried out in 53-blood samples: 52 patients with de novo ALL and one with relapsed ALL. The ETV6-RUNX1 fusion was found in 7 cases (13.5%), BCR-ABL fusion was detected in 2 cases (3.8%), and 6 patients (11.5%) expressed the chimeric gene E2A-PBX1. The prevalence of E2A-PBX1 is one of the highest that has been described thus far in childhood ALL. Furthermore, we detected both the BCR-ABL, and E2A-PBX1 fusion in the relapsed patient. With regards to the immunophenotype, ETV6-RUNX1 was expressed in both pre-B and T-cell cases, while the presence of E2A-PBX1 and BCR-ABL was associated with the pre-B ALL phenotype. The prevalence of E2A-PBX1 in Mexican pediatric cases supports the existence of ethnic differences in the frequency of molecular markers of ALL. © 2008 Elsevier Ltd. All rights reserved. |
| Colaborador(es) u otros Autores: | Miranda-Peralta E. Saldaña-Alvarez Y. Perez-Vera P. Paredes-Aguilera R. Rivera-Luna R. Velázquez-Cruz R. Ramírez-Bello J. Carnevale A. Orozco L. |
| Fecha de publicación : | 2008 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1016/j.leukres.2008.03.021 |
| Fuente: | Leukemia Research 32(10):1518 - 1522 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2106 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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