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Título : Benign cephalic histiocytosis progressing into juvenile xanthogranuloma: A non-Langerhans cell histiocytosis transforming under the influence of a virus?
Creador: Rodriguez Jurado R.,
Nivel de acceso: Open access
Palabras clave : Varicela - complicaciones
Preescolar
Progresión de la Enfermedad
Femenino
Histiocitos - patología
Histiocitosis de Células no Langerhans - patología
Histiocitosis de Células no Langerhans - virología
Humanos
Piel - patología
Piel - ultraestructura
Xantogranuloma Juvenil - patología
Xantogranuloma Juvenil - virología
Chickenpox - complications
Child, Preschool
Disease Progression
Female
Histiocytes - pathology
Histiocytosis, Non-Langerhans-Cell - pathology
Histiocytosis, Non-Langerhans-Cell - virology
Humans
Skin - pathology
Skin - ultrastructure
Xanthogranuloma, Juvenile - pathology
Xanthogranuloma, Juvenile - virology
Histiocitosis cefálica benigna
Xanthogranuloma, Juvenile
Xantoma Diseminado
Herpesvirus Humano 3
Benign cephalic histiocytosis
Juvenile xanthogranuloma
Non-Langerhans cell histiocytosis
Varicella-zoster
Descripción : Benign cephalic histiocytosis (BCH) is best understood as a form of non- Langerhans cell histiocytosis, specifically as an early mononuclear variant of juvenile xanthogranuloma (JXG). However, the progression of BCH into JXG in the same patient has only been reported once before. We describe the case of a 2-year-old girl with asymptomatic, large, ill-defined infiltrated flat plaques over both cheeks, in addition to isolated papules. A punch biopsy of a plaque revealed dermal infiltration by vacuolated and scalloped histiocytes positive for CD68 KP-1, and that lacked expression of CD1a and S-100 protein, favoring macrophages over Langerhans cells. Electron microscopy study showed comma-shaped intracytoplasmic bodies in the histiocytic cells leading to the diagnosis of BCH. One year later, after an episode of varicella-zoster infection, the flat plaques over the cheeks became large reddish-yellow nodules, and in a second biopsy appeared to progress to JXG. Virus-related mechanisms of progression are discussed.
Colaborador(es) u otros Autores: Duran-McKinster C.
Ruiz-Maldonado R.
Fecha de publicación : 2000
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1097/00000372-200002000-00014
Fuente: American Journal of Dermatopathology 22(1):70 - 74
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2108
Idioma: eng
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