Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2115
Título : Bioavailability of an extemporaneous suspension of propafenone made from tablets
Creador: Juárez Olguín, Mateo Hugo
Nivel de acceso: Open access
Palabras clave : Administración Oral - Conejos
Antiarrítmicos - administración & dosificación - Conejos
Antiarrítmicos - sangre - Conejos
Antiarrítmicos - farmacocinética - Conejos
Disponibilidad Biológica - Conejos
Estabilidad de Medicamentos - Conejos
Inyecciones Intravenosas - Conejos
Propafenona - administración & dosificación - Conejos
Propafenona - sangre - Conejos
Propafenona - farmacocinética - Conejos
Suspensiones - Conejos
Comprimidos - Conejos
Administration, Oral - Rabbits
Anti-Arrhythmia Agents - administration & dosage - Rabbits
Anti-Arrhythmia Agents -blood - Rabbits, Anti-Arrhythmia Agents - pharmacokinetics - Rabbits
Biological Availability - Rabbits
Drug Stability - Rabbits
Injections, Intravenous - Rabbits
Propafenone -administration & dosage - Rabbits
Propafenone - blood - Rabbits
Propafenone - pharmacokinetics - Rabbits
Suspensions - Rabbits
Tablets - Rabbits
Antiarrítmicos
Propafenona
Suspensiones
Comprimidos
Conejos
Anti-Arrhythmia Agents
Propafenone
Suspensions
Tablets
Rabbits
Descripción : Propafenone is an effective antiarrhythmic agent used in children, while in Mexico no specific formulation for children is available, which causes errors in adequate dosage. The aim of this study was to determine the bioavailability of a suspension prepared extemporaneously using commercial tablets of propafenone. The bioavailability was determined in two groups of rabbits (n = 8): the first group received a single intravenous dose of 2 mg/kg of propafenone; the second was orally administered an extemporaneous suspension of propafenone prepared from commercial tablets. Blood samples were drawn at several times during the next 24 h and analysed by HPLC to determine drug levels. The extemporaneous suspension was tested previously with satisfactory results regarding physicochemical and microbiologic stability. The area under the curve (AUC) for the i.v. route was 5600.6 ng/ml.h and for oral administration the AUC was 3327.6 ng/ml.h. The bioavailability was calculated at 59.41%. These results are consistent with previous reports for solid dosage forms. The propafenone suspension prepared extemporaneously using commercial tablets is bioavailable using an animal model; nevertheless, it is necessary to carry out human studies either in volunteers or in patients to confirm these results. Copyright © 2006 John Wiley & Sons, Ltd
Colaborador(es) u otros Autores: Flores Pérez Carmen
Flores Pérez Janett
Ramíres Mendiola Blanca
Carrasco Portugal Miriam
Bobadilla Chávez Jesús
Fecha de publicación : 2006
Tipo de publicación: Artículo
Formato: PDF
Identificador del Recurso : 10.1002/bdd.505
Fuente: Biopharmaceutics and Drug Disposition 27(5):241-245
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2115
Idioma: eng
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