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Título : Biotin deficiency and biotin excess: effects on the female reproductive system
Creador: Báez Saldaña, Armida
Nivel de acceso: Open access
Palabras clave : Biotina - administración & dosificación - ratones
Biotina - sangre - ratones
Biotina - deficiencia - ratones
Biotina - farmacología - ratones
Peso Corporal - efectos de drogas - ratones
Dieta - ratones
Estradiol - sangre - ratones
Ciclo Estral - efectos de drogas - ratones
femenino - ratones
Hígado - anatomía & histología - ratones
Hígado - efectos de drogas - ratones
Hígado - enzimología - ratones
Ratones Consanguíneos BALB C
Tamaño de los Órganos - efectos de drogas - ratones
Ovario - anatomía & histología - ratones
Ovario - efectos de drogas - ratones
Progesterona - sangre - ratones
ARN Mensajero - metabolismo - ratones
Receptores de Estradiol - genética - ratones
Receptores de Progesterona - genética - ratones
Reproducción - efectos de drogas - ratones
Reproducción - fisiología - ratones
Útero - efectos de drogas - ratones
Útero - metabolismo - ratones
Biotin - administration & dosage - Mice
Biotin - blood - Mice
Biotin - deficiency - Mice
Biotin - pharmacology- Mice
Body Weight - drug effects - Mice
Diet - Mice
Estradiol - blood - Mice
Estrous Cycle - drug effects - Mice
Female - Mice
Liver - anatomy & histology - Mice
Liver -drug effects - Mice
Liver - enzymology - Mice
Mice, Inbred BALB C
Organ Size - drug effects - Mice
Ovary - anatomy & histology - Mice
Ovary - drug effects - Mice
Progesterone - blood - Mice
RNA, Messenger - genetics - Mice
RNA, Messenger - metabolism - Mice
Receptors, Estradiol - genetics - Mice
Receptors, Progesterone - genetics - Mice
Reproduction - drug effects - Mice
Reproduction - physiology - Mice
Uterus - drug effects - Mice
Uterus - metabolism - Mice
Biotina, Estradiol, Progesterona, Receptores de esteroides sexuales, CYP, Ovario
Biotin Estradiol Progesterone Sex steroid receptors CYP Ovary
Descripción : Biotin deficiency and biotin excess have both been found to affect reproduction and cause teratogenic effects. In the reproductive tract, however, the effects of biotin have not been well established yet. We investigated the effects of varying biotin content diets on the oestrus cycle, ovarian morphology, estradiol and progesterone serum levels, and the uterine mRNA abundance of their nuclear receptors, as well as on the activity of the estradiol-degrading group of enzymes cytochrome P450 (CYP) in the liver. Three-week-old female BALB/cAnN Hsd mice were fed a biotin-deficient, a biotin-control, or a biotin-supplemented diet (0, 7.2 or 400 micromol of free biotin/kg diet, respectively) over a period of nine weeks. Striking effects were observed in the biotin-deficient group: mice showed arrested estrous cycle on the day of diestrus and changes in ovary morphology. Estradiol serum concentration increased 49.2% in biotin-deficient mice compared to the control group, while the enzymatic activities of CYP1A2 and CYP2B2 increased (P<0.05). The mRNA abundance of nuclear estrogen and progesterone receptors decreased in the biotin-deficient mice. In the biotin-supplemented group we found that, in spite of a significant (P<0.05) decrease in the number of primary and Graafian follicles and in CYP1A2 activities, mice exhibited 105.4% higher serum estradiol concentration than the control group. No changes in the expression of the nuclear receptors were observed. No significant differences were observed in serum progesterone among the groups. Our results indicate that both the deficiency and the excess of biotin have significant effects on the female mouse reproductive system
Colaborador(es) u otros Autores: Camacho-Arroyo I
Espinosa-Aguirre JJ
Neri-Gómez T
Rojas-Ochoa A
Guerra-Araiza C
Larrieta E
Vital P
Díaz G
Chavira R
Fernández-Mejía C.
Fecha de publicación : 2009
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1016/j.steroids.2009.06.004
Fuente: Steroids 74(10-11):863-69
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2118
Idioma: eng
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