Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2129
Título : Brain thiobarbituric acid-reactive substances in rats after short periods of ozone exposure
Creador: Escalante Membrillo C
Nivel de acceso: Open access
Palabras clave : Contaminantes del Aire - toxicidad
Cerebro - efectos de drogas
Peroxidación de Lípido - Efectos de drogas
Ozono - Toxicidad
Sustancias Reactivas al Ácido Tiobarbitúrico - Metabolismo
Ratas
Air Pollutants - Toxicity
Brain - Drug effects
Lipid Peroxidation - Drug effects
Ozone - Toxicity
Thiobarbituric Acid Reactive Substances - Metabolism
Rats
Ozono
 Peroxidación de los lípidos
 TBARS
 Cerebro
 Radicales libres
Ozone
Lipid peroxidation
TBARS
Brain
Free radicals
Descripción : It has been proposed that molecules derived from reactions that occur between the ozone and the lung tissue mediate nonpulmonary effects caused by ozone exposure. Free radicals are among those proposed molecules that flow throughout the bloodstream to other organs producing lipid peroxidation. In order to elucidate on aspect of ozone toxicity mechanisms, we measured the thiobarbituric acid-reactive products (TBARS), as an index of lipid peroxidation, in a variety of brain regions in rats exposed to 1 ppm of ozone for 1, 3, 6, and 9 h. Another group exposed to 9 h of O3 plus 3 h of clean-air exposure was also included. The results showed an important increase in TBARS content in all the studied structures. Such effect seems to be transient. These findings indicates that acute ozone exposure can produce cerebral peroxidation as it has been found in rats exposed chronically, suggesting an involvement of free radicals in brain effects of ozone exposure.
Colaborador(es) u otros Autores:  Gonzalez Maciel A
 Reynoso Robles R
 Gonzalez Pina R.
Fecha de publicación : 2005
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1016/j.envres.2005.02.006
Fuente: Environmental Research 99(1):68-71
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2129
Idioma: eng
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