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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2130| Título : | Breastfeeding and early infection in the aetiology of childhood leukaemia in Down syndrome |
| Creador: | Flores Lujano J |
| Nivel de acceso: | Open access |
| Palabras clave : | Lactancia Materna - efectos adversos Estudios de Casos y Controles Síndrome de Down - complicaciones Síndrome de Down - diagnóstico Síndrome de Down - epidemiología niño recién nacido Infección - complicaciones Infección - epidemiología Leucemia Mieloide - complicaciones Leucemia Mieloide - diagnóstico Leucemia Mieloide - epidemiología Leucemia-Linfoma Linfoblástico de Células Precursoras - complicaciones Leucemia-Linfoma Linfoblástico de Células Precursoras - diagnóstico Leucemia-Linfoma Linfoblástico de Células Precursoras - epidemiología Breast Feeding- adverse effects Case-Control Studies Down Syndrome - complications Down Syndrome - diagnosis Down Syndrome - epidemiology child Infant, Newborn Infection - complications Infection - epidemiology Leukemia, Myeloid - complications Leukemia, Myeloid - diagnosis Leukemia, Myeloid - epidemiology Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis Precursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology leucemia, Síndrome de Down, lactancia materna, infecciones leukaemia, Down syndrome, breastfeeding, infections |
| Descripción : | Background: For a child to develop acute leukaemia (AL), environmental exposure may not be sufficient: interaction with a susceptibility factor to the disease, such as Down syndrome (DS), may also be necessary. We assessed whether breastfeeding and early infection were associated with the risk of developing AL in children with DS.Methods:Children with DS in Mexico City, and either with or without AL, were the cases (N57) and controls (N218), respectively. Population was divided in children with AL and with acute lymphoblastic leukaemia (ALL) and also in children 6 and 6 years old.Results:Breastfeeding and early infections showed moderate (but not significant) association for AL, whereas hospitalisation by infection during the first year of life increased the risk: odds ratios (confidence interval 95%) were 0.84 (0.43-1.61), 1.70 (0.82-3.52); and 3.57 (1.59-8.05), respectively. A similar result was obtained when only ALL was analysed.Conclusion:We found that breastfeeding was a protective factor for developing AL and ALL, and during the first year of life, infections requiring hospitalisation were related to a risk for developing the disease in those children with DS 6 years of age. These data do not support the Greaves's hypothesis of early infection being protective for developing ALL. © 2009 Cancer Research UK. |
| Colaborador(es) u otros Autores: | Perez-Saldivar ML Fuentes-Pananá EM Gorodezky C Bernaldez-Rios R Del Campo-Martinez MA Martinez-Avalos A Medina-Sanson A Paredes-Aguilera R De Diego-Flores Chapa J Bolea-Murga V Rodriguez-Zepeda MC Rivera-Luna R Palomo-Colli MA Romero-Guzman L Perez-Vera P Alvarado-Ibarra M Salamanca-Gómez F Fajardo-Gutierrez A Mejía-Aranguré JM |
| Fecha de publicación : | 2009 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1038/sj.bjc.6605244 |
| Fuente: | British Journal of Cancer 101(5):860 - 864 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2130 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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