Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2132
Título : A multi-country study of intussusception in children under 2 years of age in Latin America: Analysis of prospective surveillance data
Creador: Sáez Llorens, Xavier
Nivel de acceso: Open access
Palabras clave : Preescolar
Estudios Transversales
Femenino
Humanos
Incidencia
Lactante
Intususcepción - epidemiología
Intususcepción - cirugía
América Latina
Masculino
Estudios Prospectivos
Vacunas contra Rotavirus
Child, Preschool
Cross-Sectional Studies
Female
Humans
Incidence
Infant
Intussusception - epidemiology
Intussusception - surgery
Latin America
Male
Prospective Studies
Rotavirus Vaccines
Children
Intussusception
Latin America
Multi country
Rotavirus
Vaccination
Descripción : Background: Intussusception (IS) is a form of acute intestinal obstruction that occurs mainly in infants and is usually of unknown cause. An association between IS and the first licensed rotavirus vaccine, a reassortant-tetravalent, rhesus-based rotavirus vaccine (RRV-TV), led to the withdrawal of the vaccine. New rotavirus vaccines have now been developed and extensively studied for their potential association with IS. This study aimed to describe the epidemiology and to estimate the incidence of IS in Latin American infants prior to new vaccine introduction.Methods: Children under 2 years of age representing potential IS cases were enrolled in 16 centers in 11 Latin American countries from January 2003 to May 2005. IS cases were classified as definite, probable, possible or suspected as stated on the Brighton Collaboration Working Group guidelines.Results: From 517 potential cases identified, 476 (92%) cases were classified as definite, 21 probable, 10 possible and 10 suspected for intussusception. Among the 476 definite IS cases, the median age at presentation was 6.4 months with 89% of cases aged <1 year. The male to female ratio was 1.5:1. The incidence of definite IS per 100,000 subject-years ranged from 1.9 in Brazil to 62.4 in Argentina for children <2 years of age, and from 3.8 in Brazil to 105.3 in Argentina for children aged <1 year. Median hospital stay was 4 days with a high prevalence of surgery as the primary treatment (65%). Most cases (88%) made a complete recovery, but 13 (3%) died. No clear seasonal pattern of IS cases emerged.Conclusions: This study describes the epidemiology and estimates the incidence of IS in Latin American infants prior to the introduction of new rotavirus vaccines. The incidence of IS was found to vary between different countries, as observed in previous studies. Trial registration: Clinical study identifier 999910/204 (SERO-EPI-IS-204). © 2013 Sáez-Llorens et al.; licensee BioMed Central Ltd.
Colaborador(es) u otros Autores: Velázquez F.R.
Lopez P.
Espinoza F.
Linhares A.C.
Abate H.
Nuñez E.
Venegas G.
Vergara R.
Jímenez A.L.
Rivera M.
Aranza C.
Richardson V.
Macias-Parra M.
Palacios G.R.
Rivera L.
Ortega-Barria E.
Cervantes Y.
Rattimann R.
Rubio P.
Acosta C.J.
Newbern C.
Verstraeten T.
Breuer T.
Fecha de publicación : 2013
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1186/1471-230X-13-95
Fuente: BMC Gastroenterology 13(1):1-8
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2132
Idioma: eng
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