Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2138
Título : Canines as sentinel species for assessing chronic exposures to air pollutants part 2. Cardiac pathology
Creador: Calderón Garcidueñas, Lilian
Nivel de acceso: Open access
Palabras clave : Contaminantes del Aire - toxicidad
Perros - fisiología
Corazón - efectos de drogas
México
Modelos animales
Miocardio - patología
Miocardio - ultraestructura
Ozono - toxicidad
Air Pollutants - toxicity
Dogs - physiology
Heart - drug effects
Mexico
Models, Animal
Myocardium - pathology
Myocardium - ultrastructure
Ozone - toxicity
la contaminación del aire ambiente
perros
miocardio
mastocitos
materia particular
ozono
miocitos apoptóticas y las células endoteliales
lesión endotelial
Ciudad de México
ambient air pollution
dogs
myocardium
mast cells
particulate matter
ozone
apoptotic myocytes and endothelial cells
endothelial injury
Mexico City
Descripción : The principal objective of this study is to evaluate by light and electron microscopy (LM, EM) the heart tissues in stray southwest and northeast metropolitan Mexico City (SWMMC, NEMMC) dogs and compare their findings to those from 3 less polluted cities (Cuernavaca, Tlaxcala, and Tuxpam). Clinically healthy mongrel dogs, including 109 from highly polluted SWMMC and NEMMC, and 43 dogs from less polluted cities were studied. Dogs residing in cities with lower levels of pollutants showed little or no cardiac abnormalities. Mexico City and Cuernavaca dogs exhibited LM myocardial alterations including apoptotic myocytes, endothelial and immune effector cells, degranulated mast cells associated with scattered foci of mononuclear cells in left and right ventricles and interventricular septum, and clusters of adipocytes interspersed with mononuclear cells. Vascular changes included scattered polymorphonuclear leukocytes (PMN) margination and microthrombi in capillaries, and small venous and arteriolar blood vessels. Small veins exhibited smooth muscle cell hyperplasia, and arteriolar blood vessels showed deposition of particulate matter (PM) in the media and adventitia. Unmyelinated nerve fibers showed endoneural and epineural degranulated mast cells. EM examination of myocardial mast cells showed distended and abundant rough endoplasmic reticulum with few secretory granules. Myocardial capillaries exhibited fibrin deposition and their endothelial cells displayed increased luminal and abluminal pinocytic activity and the formation of anemone-like protrusions of the endothelium into the lumen. A close association between myocardial findings, lung epithelial and endothelial pathology, and chronic inflammatory lung changes was noted. The myocardial changes described in dogs exposed to ambient air pollutants may form the basis for developing hypothesis-driven mechanistic studies that might explain the epidemiological data of increased cardiovascular morbidity and mortality in people exposed to air pollutants.
Colaborador(es) u otros Autores: Gambling TM
Acuña H
García R
Osnaya N
Monroy S
Villarreal Calderón A
Carson J
Koren HS
Devlin RB
Fecha de publicación : 2001
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1093/toxsci/61.2.356
Fuente: Toxicological Sciences 61(2):356 - 367
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2138
Idioma: eng
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