Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2145
Título : Castration modifies aortic vasoreactivity and serum fatty acids in a sucrose-fed rat model of metabolic syndrome
Creador: Perez I
Nivel de acceso: Open access
Palabras clave : Aorta - metabolismo - ratas
Aorta - fisiopatología - ratas
Presión Sanguínea - ratas
Peso Corporal - ratas
Sacarosa en la Dieta - ratas
Ácidos Grasos - sangre - ratas
Hemodinámica - ratas
Síndrome X Metabólico - metabolismo - ratas
Síndrome X Metabólico - fisiopatología - ratas
Síndrome X Metabólico - prevención & control - ratas
Orquiectomía - - ratas
Ratas Wistar
Testosterona - sangre - ratas
Factores de Tiempo
Triglicéridos - sangre - ratas
Vasoconstricción - ratas
Vasodilatación - ratas
Aorta - metabolism - rats
Aorta - physiopathology - rats
Blood Pressure
Body Weight - rats
Dietary Sucrose - rats
Fatty Acids - blood - rats
Hemodinámica - rats
Metabolic Syndrome X - metabolism - rats
Metabolic Syndrome X - physiopathology - rats
Metabolic Syndrome X - prevention & control - rats
Orchiectomy - rats
Rats, Wistar
Testosterone - blood - rats
Time Factors
Triglycerides - blood - rats
Vasoconstriction - rats
Vasodilation - rats
Síndrome metabólico de la rata, Castración, Vascular, reactividad, Ácidos grasos libres
Rat metabolic syndrome · Castration · Vascular reactivity · Free fatty acids
Descripción : Levels of testosterone and estradiol influence the incidence of cardiovascular diseases: generally, estrogens in females are protective before menopause; coronaropathies, hypertension, and dyslipidemias in normal men are more frequent at comparable ages. We investigated the modulation by castration of in vitro vasoreactivity, serum lipid content, and systolic blood pressure (SBP) in rats with sucrose-induced metabolic syndrome. The main characteristics of the rat model are: hypertriglyceridemia, moderately high blood pressure, intra-abdominal accumulation of adipose tissue, hyperinsulinemia, nephropathy, increased oxidative stress, and altered vasoreactivity. Male weanling rats received 30% sucrose solution for 16 weeks (metabolic syndrome; MS), controls (C) had plain water; both had commercial rodent chow. They were subdivided into five groups with two subgroups each: Group 1, intact C and MS rats, Groups 2-5, C and MS rats castrated for periods of 16, 12, 8, and 4 weeks. At the end of the study period, systolic blood pressure was measured, and blood and aortas were obtained for fatty acid determination and vasoreactivity assays, respectively. After 16 weeks' sucrose treatment MS aortas showed hypercontractility and decreased vasodilation. Palmitic and palmitoleic acids were increased in MS versus C. Arachidonic acid levels in MS were lower than in intact or castrated C. Long-term castration of 16 weeks normalized the levels of palmitic and oleic acids. With the shorter periods of castration, contractility increased and relaxation decreased in C and MS, but it was more significant in C. Regarding fatty acid composition, long-term castration increased polyunsaturated (arachidonic and eicosapentaenoic) fatty acids. The shorter periods did not modify the fatty acid profile in either C or MS. Metabolic syndrome altered SBP, aortic reactivity, and levels of fatty acids; castration of long duration normalized them in some cases
Colaborador(es) u otros Autores: El Hafidi M
Carvajal K
Baños G
Fecha de publicación : 2009
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1007/s00380-008-1098-x
Fuente: Heart Vessels 24(2):147-55
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2145
Idioma: eng
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