Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2157
Título : Changes in Angiotensin Receptor Distribution and in Aortic Morphology Are Associated with Blood Pressure Control in Aged Metabolic Syndrome Rats
Creador: Guarner Lans Verónica
Nivel de acceso: Open access
Palabras clave : Receptores de Angiotensina - ultraestructura, Receptores de Angiotensina - sangre
Receptores de Angiotensina - metabolismo
Receptores de Angiotensina - uso terapéutico
Aorta Torácica - anatomía & histología
Aorta Torácica - patología
Aorta Torácica - embriología
Aorta Torácica -química
Aorta Torácica - ultraestructura
Aorta Torácica - metabolismo
Presión Arterial - fisiología
Microscopía Electrónica
Fluorescencia
Trastornos del Metabolismo de los Lípidos - terapia
Trastornos del Metabolismo de los Lípidos - inducido químicamente
Trastornos del Metabolismo de los Lípidos - patología
Trastornos del Metabolismo de los Lípidos - sangre
Endotelio Vascular - citología
Endotelio Vascular - ultraestructura
Endotelio Vascular - embriología
Endotelio Vascular - patología
Receptors, Angiotensin - ultrastructure
Receptors, Angiotensin - blood
Receptors, Angiotensin - metabolism
Receptors, Angiotensin - therapeutic use
Aorta, Thoracic - anatomy & histology
Aorta, Thoracic - pathology
Aorta, Thoracic - embryology
Aorta, Thoracic - chemistry
Aorta, Thoracic - ultrastructure
Aorta, Thoracic - metabolism
Arterial Pressure - physiology
Microscopy, Electron
Fluorescence
Lipid Metabolism Disorders - therapy
Lipid Metabolism Disorders - chemically induced
Lipid Metabolism Disorders - pathology
Lipid Metabolism Disorders - blood
Endothelium, Vascular - cytology
Endothelium, Vascular - ultrastructure
Endothelium, Vascular - embriology
Endothelium, Vascular - pathology
Angiotensina, Arco de la Aorta, metabolismo, Endotelio Capilar
Angiotensins, Aorta, Thoracic , metabolism, Endothelium, Vascular
Descripción : The role of the renin-angiotensin system (RAS) in blood pressure regulation in MS during aging is unknown. It participates in metabolic syndrome (MS) and aging regulating vascular tone and remodeling. RAS might participate in a compensatory mechanism decreasing blood pressure and allowing MS rats to reach 18 months of age and it might form part of therapeutical procedures to ameliorate MS. We studied histological changes and distribution of RAS receptors in aortas of MS aged rats. Electron microscopy images showed premature aging in MS since the increased fibrosis, enlarged endothelium, and invasion of this layer by muscle cells that was present in control 18-month-old aortas were also found in 6-month-old aortas from MS rats. AT1, AT2, and Mas receptors mediate the effects of Ang II and Ang 1-7, respectively. Fluorescence from AT2 decreased with age in control and MS aortas, while fluorescence of AT1 increased in aortas from MS rats at 6 months and diminished during aging. Mas expression increased in MS rats and remained unchanged in control rats. In conclusion, there is premature aging in the aortas from MS rats and the elevated expression of Mas receptor might contribute to decrease blood pressure during aging in MS. © 2016 Verónica Guarner-Lans et al.
Colaborador(es) u otros Autores: Soria-Castro Elizabeth
Rocío Torrico-Lavayen Rocío
Patrón-Soberano Araceli
Carvajal-Aguilera Karla G.
Castrejón-Tellez Vicente
Rubio-Ruiz María Esther
Fecha de publicación : 2016
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1155/2016/5830192
Fuente: International Journal of Hypertension 2016():1 - 11
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2157
Idioma: eng
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