Por favor, use este identificador para citar o enlazar este ítem:
http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2204| Título : | Comparative effect of cyanamide and sodium nitroprusside on indolamine and lipid peroxidation levels in rat brain |
| Creador: | Calderón Guzmán, David |
| Nivel de acceso: | Open access |
| Palabras clave : | Química Encefálica - efectos de drogas Cianamida - farmacología Indoles - metabolismo Peroxidación de Lípido - efectos de drogas Nitroprusiato - farmacología Ratas Indoles Nitratos Nitroprusiato Serotonina Cianamida Brain Chemistry - Drug effects Cyanamide - Pharmacology Lipid Peroxidation - Drug effects Nitroprusside - Pharmacology Rats Indoles Nitrates Nitroprusside Serotonin Cyanamide cyanamide; indoleamine; nitrate; nitric oxide; nitrite; nitroprusside sodium; serotonin; thiobarbituric acid reactive substance; tryptophan; animal cell; animal experiment; animal model; animal tissue; brain homogenate; conference paper; controlled study; decapitation; drug activity; drug effect; lipid peroxidation; liquid chromatography; male; nonhuman; oxidative stress; rat; Animals; Biogenic Amines; Brain Chemistry; Chromatography, High Pressure Liquid; Cyanamide; Indicators and Reagents; Indoles; Lipid Peroxidation; Male; Nitrates; Nitric Oxide; Nitroprusside; Rats; Rats, Wistar; Serotonin; Spectrophotometry, Ultraviolet; Thiobarbituric Acid Reactive Substances |
| Descripción : | The aim of this study was to compare the effect of cyanamide (CNM) and sodium nitroprusside (SNP) on nitrite (NO 2 -) and nitrate (NO 3 -), stable metabolites of nitric oxide (NO), serotonin (5-HT), tryptophan (Trp), and lipid peroxidation (TBARS) levels in rat brain. Twenty-four male Wistar rats (350 g) were used, divided in 3 groups of 8 animals each. Control group I received 0.9 % NaCl, CNM (40 mg/kg) was administered to group II, and SNP (20 pg/kg) to group III; all animals received a single intraperitoneal dose. The animals were sacrificed by decapitation and the brain was homogenized to measure the NO 2 -, NO 3 -, 5-HT, and Trp levels by liquid chromatography, and TBARS levels by spectrophotometry. NO 2 - levels significantly increased (p < 0.01) in the CNM group, while 5-HT and TBARS significantly increased (p = 0.001) both in SNP and CNM groups in relation to the control group. Trp levels presented a slight increase in the CNM group with respect to the control group. The results suggest that free radicals (Nitroxyl and NO) generated by CNM and SNP, respectively, are responsible for oxidative stress induced in brain. |
| Colaborador(es) u otros Autores: | Espitia Vazquez Ivonne Barragan Mejía Gerardo Hernández García Ernestina Huerta Gertrudis Bernardino Coballase Urrutia Elvia Santamaria Del Angel Daniel Juárez Olguin Hugo |
| Fecha de publicación : | 2004 |
| Tipo de publicación: | Otros |
| Formato: | |
| Fuente: | Proceedings of the Western Pharmacology Society 47():105 - 108 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2204 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.