Por favor, use este identificador para citar o enlazar este ítem:
http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2205| Título : | Comparative effects of catechin, epicatechin and N-Ω- nitroarginine on quinolinic acid-induced oxidative stress in rat striatum slices |
| Creador: | Santamaría Del Ángel Daniel |
| Nivel de acceso: | Open access |
| Palabras clave : | Animales Catequina - farmacología Cuerpo Estriado - patología Disulfuro de Glutatión - metabolismo Peroxidación de Lípido - efectos de drogas Lípidos - química masculino Nitroarginina - farmacología Estrés Oxidativo - efectos de drogas Ácido Quinolínico - toxicidad Ratas Wistar Animals Catechin - pharmacology Corpus Striatum - pathology Glutathione Disulfide - metabolism Lipid Peroxidation - drug effects Lipids - chemistry Male Nitroarginine - pharmacology Oxidative Stress - drug effects Quinolinic Acid - toxicity Rats, Wistar Cerebro; Excitotoxicidad; Flavonoides; Gluthation; Peroxidación de los lípidos; Óxidonítrico; Daño oxidativo Brain; Excitotoxicity; Flavonoids; Gluthation; Lipid Peroxidation; Nitric oxide; Oxidative damage |
| Descripción : | The aim of this work was to compare the effects of catechin (CAT), epicatechin (EPI) and N-ω-l-nitroarginine (L-NARG) on different endpoints of oxidative stress induced by quinolinic acid (QUIN) in a simple tissue preparation, rat striatal slices - with particular emphasis in the glutathione system - in order to provide revealing information on the antioxidant efficacy of these agents in an excitotoxic model. Methods: Rat striatal slices were incubated for 1 h in the presence of 100 μM QUIN and/or 85 μM CAT or EPI, or 100 μM L-NARG. Lipid peroxidation (LP) and the levels of reduced and oxidized glutathione (GSH and GSSG) were determined. Results: The three agents tested completely blocked the QUIN-induced lipid peroxidation and recovered the QUIN-induced altered GSH/GSSG balance. No statistical differences were detected among the protective effects exerted by these antioxidants, suggesting similar efficacy and common antioxidant mechanisms. The antioxidant properties exhibited by these molecules on the excitotoxic model tested herein support an active role of glutathione and prompt their use as therapeutic tools in models of neurodegenerative disorders. © 2016 Elsevier Masson SAS. |
| Colaborador(es) u otros Autores: | Labra Ruíz Norma Angélica García-Cruz Mercedes Edna Calderón Guzmán David Valenzuela Peraza Armando Juárez-Olguín Hugo |
| Fecha de publicación : | 2016 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1016/j.biopha.2016.01.016 |
| Fuente: | Biomedicine and Pharmacotherapy 78():210 - 215 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2205 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.