Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2234
Título : CYP2D6 genotype and phenotype in Amerindians of Tepehuano origin and Mestizos of Durango, Mexico
Creador: Sosa Macias M
Nivel de acceso: Open access
Palabras clave : Citocromo P-450 CYP2D6 - genética
Citocromo P-450 CYP2D6 - metabolismo
ADN - análisis
Dextrometorfano - sangre
Dextrometorfano - farmacocinética
Dextrorfano - sangre
Frecuencia de los Genes - genética
Genotipo - genética
Indios Norteamericanos - genética
Mediana Edad - Masculino - México
fenotipo - genética
Polimorfismo Genético - genética
Cytochrome P-450 CYP2D6 -genetics
Cytochrome P-450 CYP2D6 - metabolism
DNA -analysis
Dextromethorphan -blood
Dextromethorphan - pharmacokinetics
Dextrorfano -blood
Gene Frequency - genetics
Genotype - genetics
Indians, North American - genetics
Middle Aged - Male - Mexico
Phenotype - genetics
Polymorphism, Genetic
frecuencia de los alelos
polimorfismo CYP2D6
diferencias étnicas
tepehuanes amerindios, Cytochrome P-450
Allele frequency
CYP2D6 polymorphism
ethnic difference
Tepehuan Amerindians
Descripción : Although the drug-metabolizing enzyme CYP2D6 has been studied extensively in subjects of differing ethnicities, limited CYP2D6 pharmacogenetic data are available for the Amerindian population and Mestizos of Mexico. Dextromethorphan hydroxylation phenotype was studied in Tepehuano Amerindian (n = 58) and Mestizo (n = 88) subjects, and 195 individuals (85 Tepehuano Amerindians and 110 Mestizos) were genotyped by polymerase chain reaction-restriction fragment length polymorphism methods to identify the frequencies of the CYP2D6*3, *4, *6, and *10 alleles. Tepehuano Amerindian subjects lacked the poor metabolizer (PM) phenotype, whereas in Mestizos the PM phenotype frequency was 6.8%. The CYP2D6*3, *6, and *10 alleles were not found in Tepehuano Amerindians. The CYP2D6*4 allele had a low frequency (0.006) in this Amerindian group. In the Mestizo group, the CYP2D6*3, *4, and *10 alleles had frequencies of 0.009, 0.131, and 0.023, respectively. The CYP2D6*6 allele was not found in Mestizos. The genotype-phenotype association was strongly statistically significant (r 2 = .45; P = .005) in Mestizos. The Tepehuano population was found to have a low phenotypic and genotypic CYP2D6 diversity and differed from other Amerindian groups. On the other hand, the frequencies of the CYP2D6 variant alleles in Mestizos were similar to those reported for whites. ©2006 the American College of Clinical Pharmacology.
Colaborador(es) u otros Autores: Elizondo Anzuela G
Flores Perez C
Flores Perez J
Bradley Alvarez F
Alanis Bañuelos R
Lares Asseff I.
Fecha de publicación : 2006
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1177/0091270006287586
Fuente: Journal of Clinical Pharmacology 46(5):527 - 536
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2234
Idioma: eng
Aparece en las colecciones: Artículos

Ficheros en este ítem:
No hay ficheros asociados a este ítem.


Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.