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Título : Detection of circulating and fecal trichinella spiralis antigens during experimental infection using monoclonal antibodies against the new born larvae
Creador: De la Rosa, JL
Nivel de acceso: Open access
Palabras clave : Animales
Anticuerpos Antihelmínticos
Antígenos Helmínticos - análisis
Antígenos Helmínticos - sangre
Trichinella spiralis - aislamiento y purificación
Trichinellosis - sangre
Trichinellosis - diagnóstico
Animals
Antibodies, Helminth
Antigens, Helminth - analysis
Antigens, Helminth - blood
Trichinella spiralis - isolation & purification
Trichinellosis - blood
Trichinellosis - diagnosis
Trichinella
antígenos
anticuerpos monoclonales
Diagnóstico
Larva recién nacida
Trichinella
antigens
monoclonal-antibody
diagnosis
new born larva.
Descripción : Different assays to detect antigens of Trichinella spiralis during current infection have been standardized, although sensitivity values have been the main limitation to use them as routine diagnostic test. We report the production and use of monoclonal antibodies (MAbs) against the new born larvae which recognize both somatic and metabolic antigens from adult and muscular larvae (ML). We used two lgG3 MAbs (4B1, 4B2) and two lgG2a (2D3, 2D4) to detect antigens during experimental infection. All MAbs detect fecal antigens starting the second to third week post infection (wpi), although it was less clear with MAbs 4B1 and 4B2, while circulating antigens were detected from third to fourth wpi. Thus, the recognition of shared antigens among T. spiralis developmental stages can be used for early diagnosis of trichinellosis.
Colaborador(es) u otros Autores: Morán Tlatelpa E
Medina Y
Gómez Priego A
Correa D
Fecha de publicación : 2001
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1051/parasite/200108s2123
Fuente: Parasite 8(2 suppl.):S123-25
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2261
Idioma: eng
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