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Título : Diabetes mellitus as a conformational disease: a novel potential therapeutic approach
Creador: Fernández Gómez, Isaac
Nivel de acceso: Open access
Palabras clave : Diabetes Mellitus Tipo 2 - terapia
Diabetes Mellitus Tipo 2 - economía
Proteínas Amiloidogénicas - uso terapéutico
Diabetes Mellitus, Type 2 - therapy
Diabetes Mellitus, Type 2 - economics
Amyloidogenic Proteins - therapeutic use
Diabetes Mellitus Tipo 2
terapia
economía
Proteínas Amiloidogénicas
Diabetes Mellitus, Type 2
therapy
economics
Amyloidogenic Proteins
Descripción : Type 2 diabetes mellitus is a conformational disease (CD), characterised by deposition (fibrils and cytotoxic oligomers) of the human islet amyloid peptide (hIAPP). CDs have devastating effects on the sufferers and their caregivers, as well as a tremendous economic impact on families and the health system. Novel molecule candidates targeting self-assembled amyloidogenic proteins represent a potential therapeutic approach for CDs. Methods/design: In this work we carried out a systematic study in order to determine the interrelation between the IAPP and IAPP 20–29 fragments in aggregation kinetic with a novel family of naphthalene compounds, used as chemical chaperones. N-(2-aminoethyl)-N′-1-naphthylsuccinamide A; methyl (2-((4-(1-naphthylamino)-4-oxobutanoyl)amino)ethyl) dithiocarbamate B; (2R)-2-(6-methoxy-2-naphthyl)propanoic acid (Naproxen) C; N-(4-(1-naphthylamino)-4-oxobutanoyl)-β-alanine D; 6-((4-(1-naphthylamino)-4-oxobutanoyl)amino) hexanoic acid E; N3,N3′-ethane-1,2-dyilbis(N1-1-naphthylsuccinamide) F; N-(4-aminobutyl)-N′-1-naphthylsuccinamide G; and (1E,6E)-1,8-bis(4-hydroxy-3-methoxyphenyl)octa-1,6-diene-3,5-dione (Curcumine). We describe the structural features, aggregation kinetics, and toxic properties of the, in presence or absence of a novel naphthalene of the chemical chaperones family.
Colaborador(es) u otros Autores: Marquiza Sablón-Carrazana1
2
Alberto Bencomo1
2
Karina Pasten-Hidalgo3
Rosa Angélica Castillo-Rodríguez3
Guadalupe Domínguez5
Reyna Lara6
Luis Felipe Jiménez6
Julio Morán5
Nelly Altamirano-Bustamante7
Sergio Islas-Andrade1
Chryslaine Rodríguez-Tanty2
Eulalia Garrido-Magaña4 & Myriam M Altamirano-Bustamante1
Fecha de publicación : 2015
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1530/endoabs.37.EP437
Fuente: Endocrine Abstracts 37():EP437
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2280
Idioma: eng
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