Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2286
Título : Dietary Biotin Supplementation Modifies Hepatic Morphology without Changes in Liver Toxicity Markers
Creador: Riverón Negrete, Leticia
Nivel de acceso: Open access
Palabras clave : Biotina - farmacología
Suplementos Dietéticos
Hepatocitos - patología
Hígado - lesiones
Hígado - metabolismo
Hígado - patología
Hepatopatías - metabolismo
Hepatopatías - patología
Biotin - pharmacology
Dietary Supplements
Hepatocytes - metabolism
Hepatocytes - pathology
Liver - injuries
Liver - metabolism
Liver - pathology
Liver Diseases - metabolism
Liver Diseases - pathology
Vitamina biotina
Coenzima de las carboxilasas
Expresión génica
Biotina hipolipidémica
Hipoglucemia
Uso farmacológico de la biotina
Secreción de insulina
Islotes pancreaticos
Toxicidad hepática
Biotin Vitamin
Coenzyme of the carboxylases
Gene Expression
Hypolipidemic biotin
Hypoglycemia
Pharmacological use of biotin
Insulin secretion
Pancreatic islets
Hepatic toxicity
Descripción : Pharmacological concentrations of biotin have pleiotropic effects. Several reports have documented that biotin supplementation decreases hyperglycemia. We have shown that a biotin-supplemented diet increased insulin secretion and the mRNA abundance of proteins regulating insulin transcription and secretion. We also found enlarged pancreatic islets and modified islet morphology. Other studies have shown that pharmacological concentrations of biotin modify tissue structure. Although biotin administration is considered safe, little attention has been given to its effect on tissue structure. In this study, we investigated the effect of biotin supplementation on hepatic morphology and liver toxicity markers. Male BALB/cAnN Hsd mice were fed a control or a biotin-supplemented diet for 8 weeks. Versus the control mice, biotin-supplemented mice had an altered portal triad with dilated sinusoids, increased vascularity, and bile conducts. Furthermore, we observed an increased proportion of nucleomegaly and binucleated hepatocytes. In spite of the liver morphological changes, no differences were observed in the serum liver damage indicators, oxidative stress markers, or antioxidant enzymes. Our data demonstrate for the first time that biotin supplementation affects liver morphology in normal mice, and that these modifications are not paralleled with damage markers. © 2016 Leticia Riverón-Negrete et al.
Colaborador(es) u otros Autores: Sicilia-Argumedo G
Álvarez-Delgado C
Coballase-Urrutia E
Alcántar-Fernández J
Fernandez-Mejia C
Fecha de publicación : 2016
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1155/2016/7276463
Fuente: BioMed Research International 2016(2016):1-9
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2286
Idioma: eng
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