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Título : Effect of EGB761 supplementation on metallothionein I + II expression after 1-methyl-4-phenylpyridinium neurotoxicity
Creador: Serrano García,Norma
Nivel de acceso: Open access
Palabras clave : Ginkgo biloba - uso terapéutico
1-Metil-4-fenilpiridinio - toxicidad
Intoxicación por MPTP - terapia
Enfermedad de Parkinson Secundaria - inducido químicamente
Ginkgo biloba - therapeutic use
1-Methyl-4-phenylpyridinium - toxicity
MPTP Poisoning - therapy
Parkinson Disease, Secondary - chemically induced
EGb761
Metallothionein I + II
1-methyl-4- phenylpyridinium
Striatum
Descripción : Metallothionein I+II(MTI+II) are neuroprotective proteins with an antioxidant action during 1-methyl-4-phenylpyridinium (MPP+) neurotoxicity, a model of Parkinson's disease. EGb761 has neuroprotective effects, via its antioxidant action. Here, we investigated whether in vivo pretreatment with EGb761 alters the expression of MT I+ II during MPP + neurotoxicicity. C-57 black mice were pretreated with EGb761 (10 mg/kg) daily for 17 days followed by administration of MPP+ (0.72 mg/kg) and were sacrificed 2 h, 24 h or 7 days later. Quantitative immunohistochemical evaluation of MT I + II expression was significantly elevated at 24 h in the striatum (21%) and substantia nigra (51%) in MPP + group. Pretreatment with EGb761 in MPP+ group regulated the MT I + II expression at 24 h to the normal levels in striatum and substantia nigra. Results suggest that EGb761-induced MT I + II expression is due to its protective action against MPP+ neurotoxicity. Copyright © 2007 by New Century Health Publishers, LLC. All rights of reproduction in any form reserved.
Colaborador(es) u otros Autores: Ulises Rodríguez-Ortiz
Julio Rojas-Castañeda
Patricia Rojas
Fecha de publicación : 2007
Tipo de publicación: Artículo
Formato: pdf
Fuente: Current Topics in Nutraceutical Research 5(2-3):83-92
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2322
Idioma: eng
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