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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2328| Título : | Effect of mannitol on the pharmacokinetics of amikacin in wistar rats |
| Creador: | Juárez Olguín, Mateo Hugo |
| Nivel de acceso: | Open access |
| Palabras clave : | Manitol - farmacocinética - ratas Manitol - administración & dosificación - ratas Manitol - análisis - ratas Manitol - sangre - ratas Amicacina - farmacocinética - ratas Amicacina - administración & dosificación - ratas Amicacina - análisis - ratas Amicacina - sangre - ratas Ratas Wistar Adulto Antibacterianos - farmacocinética - ratas Diuréticos - farmacocinética - ratas Mannitol - pharmacokinetics - rats Mannitol - administration & dosage - rats Mannitol - analysis - rats Mannitol - blood - rats Amikacin - pharmacokinetics - rats Amikacin - administration & dosage - rats Amikacin - analysis - rats Amikacin - blood - rats Rats, Wistar Adult Anti-Bacterial Agents - pharmacokinetics - rats Diuretics - pharmacokinetics - rats Farmacocinética, interacciones, amikacina, amikacina, manitol, antibióticos, diuréticos Pharmacokinetics; interactions; amikacin, mannitol; antibiotics; diuretics |
| Descripción : | The study analyzed the effect of mannitol on the pharmacokinetics (PK) of amikacin. Adult Wistar rats were treated as follows: Group 1 (G1) received mannitol for three days, Group 2 (G2) received mannitol plus 10 mg/kg of amikacin simultaneously, and Group 3 only amikacin. The PK study was conducted on the 4th day. For which, blood samples were drawn at fixed times during 24 h and immunoenzymatically analyzed. Results revealed significant differences (p<0.05) between the groups, e.g. Cmax were 62.26 ± 15.75 mg/ml for G1, 72.63 ± 24.80 mg/ml for G2 and 68.61 ± 27.40 mg/ml for G3. The AUC also differed in the three groups, being largest for G2, 222.52 ± 47.30 mg/ml/h, and smallest for G1, 135.59 ± 39.00 mg/ml/h. Alteration of the PK parameters observed between the groups must be considered when both drugs are prescribed, although human studies are necessary to confirm the results. |
| Colaborador(es) u otros Autores: | Carrasco Portugal Miriam Flores Pérez Janett Camacho Vieyra Angélica Flores Pérez Carmen Alfaro Rodríguez Alfonso |
| Fecha de publicación : | 2009 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1590/S1516-89132009000400006 |
| Fuente: | Brazilian Archives of Biology and Technology 52(4):835 - 839 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2328 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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