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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2332| Título : | A simple method for quantification of lidocaine and its metabolite monoethylglycine xylidide in plasma |
| Creador: | López A.T., |
| Nivel de acceso: | Open access |
| Palabras clave : | Lidocaína - sangre Lidocaína - farmacocinética Hidróxido de Sodio - sangre Cloruro de Metileno - sangre Cromatografía Liquida Extracción Líquido-Líquido Análisis Cuantitativo Anestésicos - farmcología Anestésicos - farmacocinética lidocaine - blood lidocaine - pharmacokinetics Sodium Hydroxide - blood Methylene Chloride - blood liquid chromatography liquid liquid extraction Quantitative Analysis Anesthetics - pharmacology Anesthetics - Pharmacokinetics Anestésico Columna de cromatografía líquida Lidocaina Monoetilglicinaxilidida Anaesthetic drug Column liquid chromatography Lidocaine Monoethylglycinexylidide |
| Descripción : | We developed a simple and fast LC method quantifying lidocaine and its metabolite monoethylglycinexylidide (MEGX) in plasma. An extraction of liquid-liquid with dichloromethane and sodium hydroxide, was done using 500 μL of plasma or serum, with a UV detection at 210 nm. The results showed linearity of r = 0.996 for lidocaine and 0.998 for MEGX. Precision and accuracy showed coefficient of variation within an acceptable range. Stability test was acceptable for a period of 90 days. Levels were assayed for two patients, in the first, 1,256.14 ng mL-1 of lidocaine and 17.79 ng mL-1 of MEGX were obtained while in the second the levels for the substances were 1,194.33 and 10.47 ng mL-1. This simple and fast method is reliable and can be recommended for the quantification of lidocaine and MEGX in plasma. © 2010 Vieweg+Teubner | GWV Fachverlage GmbH. |
| Colaborador(es) u otros Autores: | Guille B.P. Vieyra G.C. Flores O. Olguin H.J. Villegas F. Zamora J.G. Soriano R. Jiménez-Bravo M. Guille G.P. |
| Fecha de publicación : | 2010 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1365/s10337-009-1462-8 |
| Fuente: | Chromatographia 71(5–6):545 - 547 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2332 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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