Por favor, use este identificador para citar o enlazar este ítem:
http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2346| Título : | Effect of severe protein-calorie malnutrition on the penetration kinetics of trimethoprim and sulfamethoxazole to the deep tissues of Wistar rats |
| Creador: | Lares Asseff, Ismael |
| Nivel de acceso: | Open access |
| Palabras clave : | Antiinfecciosos aministración y dosis - administración y dosis Antiinfecciosos - farmacocinética Proteínas en la Dieta - administración y dosis Esquema de Medicación Riñón - metabolismo hígado - metabolismo pulmón - metabolismo Desnutrición Combinación Trimetoprim y Sulfametoxazol - administración y dosis Combinación Trimetoprim y Sulfametoxazol - Farmacocinética Anti-Infective Agents - administration & dosage Anti-Infective Agents - pharmacokinetics Dietary Proteins - administration & dosage Drug Administration Schedule Kidney - metabolism Liver - metabolism Lung - metabolism Malnutrition Trimethoprim, Sulfamethoxazole Drug Combination - administration & dosage Trimethoprim, Sulfamethoxazole Drug Combination - pharmacokinetics |
| Descripción : | This study shows the effect that severe malnourishment has on the kinetics of antibiotic penetration in tissues. A total of 104 male Wistar rats, 21 days old, were randomly divided into eight groups. Five groups of experimental rats were severely malnourished (SM) and three further groups were considered well-nourished control groups (WN). A single dose of trimethoprim-sulfamethoxazole (TMP-SMX) was administered intraperitoneally. Blood samples were taken by heart puncture and five organs were extracted 0-24 h after the administration of the drug. HPLC was used to assess the amount of trimethoprim and sulfamethoxazole in fluids. The elimination half-life for trimethoprim from plasma was longer in SM rats with a median of 3.15 h; in WN rats, it was 0.390 h. Clearance was slower in SM rats: 646.72 mL μg-1h-1 vs 3036.38 mL μg-1h-1 in WN rats (P<0.05). Tissue penetration was much higher for trimethoprim, with penetration indexes of 0.80-5.66 in WN rats, compared with 0.35-2.14 in SM rats. In the case of sulfamethoxazole, penetration indexes were 0.029-1.13 for WN and 0.075-0.657 for SM rats. Similarly, the penetration ratio to muscle and heart tissue was lower in SM rats. However, penetration to kidney, lung, liver and spleen was greater in SM rats. It is evident that severe SM decreases the capacity of trimethoprim more importantly than sulfamethoxazole biotransformation. |
| Colaborador(es) u otros Autores: | Pérez MG Camacho GA Toledo AR del Carmen López M Guillé AJ Sosa MG |
| Fecha de publicación : | 2003 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1211/0022357021026 |
| Fuente: | Journal of Pharmacy and Pharmacology 55(4):469 - 477 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2346 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.