Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2349
Título : Effect of sibutramine on Na+, K+ ATPase activity and tryptophan levels on male and female rat brain.
Creador: Guzman, David C
Nivel de acceso: Open access
Palabras clave : Encéfalo - efectos de drogas - ratas
Encéfalo - enzimología - ratas
Encéfalo - metabolismo - ratas
Ciclobutanos - administración & dosificación - ratas
Radicales Libres - metabolismo - ratas
peroxidación de lípido - efectos de drogas - ratas
Distribución Aleatoria
Ratas Wistar
Caracteres Sexuales
ATPasa Intercambiadora de Sodio-Potasio - genética - ratas
ATPasa Intercambiadora de Sodio-Potasio - metabolismo - ratas
Triptófano - metabolismo - ratas
Brain - drug effects - rats
Brain - enzymology - rats
Brain - metabolism - rats
Cyclobutanes - administration & dosage - rats
Free Radicals - metabolism - rats
Lipid Peroxidation - drug effects - rats
Random Allocation
Rats, Wistar
Sex Characteristics
Sodium-Potassium-Exchanging ATPase - genetics - rats
Sodium-Potassium-Exchanging ATPase - metabolism - rats
Tryptophan - metabolism - rats
obesidad, radicales libres, ATPasa, triptófano, cerebro
obesity - free radicals - ATPase - tryptophan - brain
Descripción : Some drugs that are clinically used in weight control, like sibutramine, act on the serotonergic metabolism, but its relation with free radical (FR) production in the CNS is still unknown. The aim of the work was to evaluate the effect of sibutramine on FR production. Female and male Wistar rats (250 g weight) were used; the animals received sibutramine (10 mg/kg each 36 hours) intraperitoneally during 15 days. At the end of the study, the rats were sacrificed and their brains used to measure lipid peroxidation (TBARS), Na+, K+ ATPase activity, reduced glutathione (GSH), and tryptophan (TRP) levels, by means of validated methods. The activity of Na+, K+ATPase and total ATPase was increased in males and decreased in females. GSH concentration was increased and the levels of TBARS decreased by an effect related to sibutramine in the female group. Sibutramine decreased TRP concentration in the female group, but increased it in the male one, with respect to the control group. Our results suggest that sibutramine produce an antioxidant effect stimulated by the endogenously produced tryptophan and it protects the fluidity of plasma membrane in rat brain.
Colaborador(es) u otros Autores: Ruíz NL
García EH
Mejía GB
Téllez PP
Jimenez GE
De la Rosa Apreza M
Olguín HJ
Fecha de publicación : 2009
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1055/s-0028-1128145
Fuente: Hormone and Metabolic Research 41(5):363 - 367
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2349
Idioma: eng
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