Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2353
Título : Effect of toluene and nutritional status on serotonin, lipid peroxidation levels and NA+/K+-ATPase in adult rat brain
Creador: Coballase Urritia, Elvia
Nivel de acceso: Open access
Palabras clave : 5-Hidroxitriptófano
Peroxidación de Lípido
Estado Nutricional
Tolueno
ATPasa Intercambiadora de Sodio-Potasio
Ratas
Cerebro - efectos de drogas
5-Hydroxytryptophan
Lipid Peroxidation
Nutritional Status
Toluene
Sodium-Potassium-Exchanging ATPase
Rats
Brain - Drugs effects
5-hidroxitriptófano
 peroxidación de los lípidos
 Estado nutricional
 Serotonina
 Tolueno
5-Hydroxytryptophan
lipid peroxidation
Nutritional status
Serotonin
Toluene
Descripción : The aim was to evaluate the effect of toluene and nutritional status on levels of serotonin (5-HT), 5-hydroxytryptophan (5-HTP), Na+/K +-ATPase, total ATPase and lipid peroxidation (TBARS) in rat brain. Study was conducted with malnourished (MN), well-nourished (WN) and normal Wistar rats. Three groups were formed for each nutritional status: control group I received 0.9% NaCl; toluene (1 g/kg) was administered to group II, and 1.5 g/kg to group III. Levels of 5-HT decreased (P < 0.05) in WN toluene groups, and 5-HTP decreased (P < 0.05) in the WN 1 g toluene and MN 1.5 g toluene groups. TBARS decreased (P < 0.05) in WN toluene groups. A trend to increase in Na+/K+-ATPase was found in WN and MN toluene groups, while total ATPase increased (P < 0.05) in the WN 1.5 g toluene group. The results suggest that high concentrations of toluene in single doses induce significant changes in the serotonergic system and alter membrane fluidity more perceptibly in the brain of adult animals with regular diet than in malnourished animals. © 2005 Springer Science+Business Media, Inc.
Colaborador(es) u otros Autores: Calderón Guzmán David
Espitia Vázquez Ivonne
López Domínguez Alejandra
Hernánez Mejía Ernestina
Huerta Gertrudis Bernardino
Coballase Urrutia Elvia
Juárez Olguín Hugo
García Fernández Beatriz
Fecha de publicación : 2005
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1007/s11064-005-2749-2
Fuente: Neurochemical Research 30(5):619 - 624
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2353
Idioma: eng
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