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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2362| Título : | Effect of quinolinic acid on endogenous antioxidants in rat corpus striatum |
| Creador: | Rodríguez Martínez, Erika |
| Nivel de acceso: | Open access |
| Palabras clave : | Ácido Quinolínico- farmacología Antioxidantes - metabolismo Cuerpo Estriado - efectos de drogas Cuerpo Estriado - enzimología Glutatión - metabolismo Disulfuro Glutatión - metabolismo Glutatión peroxidasa - metabolismo Superóxido dismutasa - metabolismo Ratas Wistar Quinolinic Acid - pharmacology Antioxidants- metabolism Corpus Striatum - drug effects Corpus Striatum - enzymology Glutathione - metabolism Glutathione Disulfide - metabolism Glutathione Peroxidase - metabolism Superoxide Dismutase - metabolism Rats, Wistar ácido quinolínico Superóxido dismutasa glutatión Glutatión peroxidasa cuerpo estriado Quinolinic acid Superoxide dismutase Glutathione Glutatione peroxidase Corpus striatum |
| Descripción : | The response of endogenous antioxidants to the N-methyl-D-aspartate (NMDA) receptor agonist and excitotoxin, quinolinic acid (QUIN), was investigated in rat corpus striatum. Animals treated with QUIN (240 nmol/microl), were sacrificed at 120 min after a single intrastriatal injection to examine the alterations in the levels of both reduced (GSH) and oxidized (GSSG) glutathione, and the activities of the antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (Gpx). Changes in the rate of lipid peroxidation (LP) were also measured after exposure to different doses of QUIN (60, 120, 240 and 480 nmol/microl) as an index of oxidative stress. When compared to control, lipid peroxidation was increased at QUIN doses of 240 and 480 nmol/microl. Striatal levels of GSH and GSSG were decreased and increased, respectively, after QUIN injection; whereas GPx activity was unchanged. Cytosolic copper/zinc SOD (CuZn-SOD) activity decreased after treatment, while mitochondrial manganese SOD (Mn-SOD) was unchanged. The alterations observed on these antioxidant systems suggest that QUIN toxicity is mediated by specific mechanisms leading to oxidative stress |
| Colaborador(es) u otros Autores: | Camacho A Maldonado PD Pedraza Chaverrí J Santamaría D Galván-Arzate S Santamaría A. |
| Fecha de publicación : | 2000 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1016/S0006-8993(99)02474-9 |
| Fuente: | Brain Res 858(2):436-439 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2362 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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