Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2381
Título : Effects of two new steroids and cyproterone on some biomarkers of oxidative stress and serotonergic system on rat prostate and brain
Creador: Calderón GD
Nivel de acceso: Open access
Palabras clave : Biomarcadores - análisis - ratas
Encéfalo - efectos de drogas - ratas
Encéfalo - metabolismo - ratas
Acetato de Ciproterona - farmacología
Glutatión - metabolismo - ratas
Ácido Hidroxiindolacético -metabolismo - ratas
Estrés Oxidativo - efectos de drogas - ratas
Estrés Oxidativo - fisiología - ratas
Pregnatrienos - farmacología - ratas
Pregnenolona - análogos & derivados - ratas
Pregnenolona - farmacología - ratas
Prostate - efectos de drogas - ratas
Prostate - ratas
Serotonina - fisiología - ratas
ATPasa Intercambiadora de Sodio-Potasio - metabolismo - ratas
Biomarkers - analysis - rats
Brain - drug effects - rats
Brain - metabolism - rats
Cyproterone Acetate - pharmacology - rats
Glutathione - metabolism - rats
Hydroxyindoleacetic Acid - metabolism - rats
Oxidative Stress - drug effects - rats
Oxidative Stress - physiology -rats
Pregnatrienes - pharmacology - rats
Pregnenolone - analogs & derivatives - rats
Pregnenolone - pharmacology - rats
Prostate - drug effects - rats
Prostate - metabolism - rats
Serotonin - physiology - rats
Sodium-Potassium-Exchanging ATPase - metabolism - rats
Thiobarbituric Acid Reactive - rats
cerebro, radicales libres, glutatión, próstata, esteróides
Brain—free radicals—glutathione— prostate—steroids
Descripción : The purpose of this study was to evaluate the effect of cyproterone acetate (CPA, A) compared with new synthetic steroids 3α-acetoxy-5,6-epoxy-16- pregnen-20-one (B) and 17α-hydroxy-16β-methyl-1,4,6-pregnatriene-3, 20-dione (C) in rat prostate and brain. Groups of animals were treated either with A, B or C (4 mg kg-1day-1) by the intraperitoneal route for 5 days. Levels of reduced glutathione (GSH), 5-hydroxy-indole acetic acid (5-HIAA), lipid peroxidation (as thiobarbituric acid reactive substances, TBARS) and the activities of Na+, K+- and total ATPases were assayed in prostate and brain for each group of animals including a control group. No appreciable changes were shown in Na+, K +-ATPase and total ATPases and TBARS on prostate and brain of rats that received A, B and C steroids. However, the levels of GSH and 5-HIAA decreased significantly (P < 0.05) in both tissues for the steroids assayed. It is concluded that CPA and the homologues B and C steroids induce changes in the levels of GSH and serotonin in rat prostate and brain. © 2009 Blackwell Publishing Ltd.
Colaborador(es) u otros Autores: Bratoeff E
Ramírez LE
Osnaya BN
García AR
Barragán MG
Hernández GE
Juárez OH
Fecha de publicación : 2009
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1111/j.1439-0272.2008.00886.x
Fuente: Andrologia 41(1):29 - 34
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2381
Idioma: eng
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