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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2456| Título : | Gene expression of CYP1A1 and its possible clinical application in thyroid cancer cases |
| Creador: | Gallegos Vargas Ja |
| Nivel de acceso: | Open access |
| Palabras clave : | Citocromo P-450 CYP1A1 - genética Femenino Expresión Génica - genética Humanos Masculino Mediana Edad ARN Mensajero - genética Factores de Riesgo Glándula Tiroides - patología Neoplasias de la Tiroides - genética Neoplasias de la Tiroides - patología Cytochrome P-450 CYP1A1 - genetics Female Gene Expression - genetics Humans Male Middle Aged RNA, Messenger - genetics Risk Factors Thyroid Gland - pathology Thyroid Neoplasms - genetics Thyroid Neoplasms - pathology Marcador molecular de tiroides cáncer - citocromo P450 1A1- Thyroid cancer - cytochrome P450 1A1 - molecular marker |
| Descripción : | Background: Thyroid cancer is the most common endocrine malignancy, and exact causes remain unknown. The role of CYP450 1A1 (CYP1A1) in cancer initiation and progression has been investigated. The aim of this work was to analyze, for the first time, CYP1A1 gene expression and its relationship with several clinicopathological factors in Mexican patients diagnosed with thyroid cancer. Materials and Methods: Real-time PCR analysis was conducted on 32 sets of thyroid tumors and benign pathologies. Expression levels were tested for correlations with clinical and pathological data. All statistical analysis were performed using GraphPad Prism version 3.0 software. Results: We found that female gender was associated with thyroid cancer risk (P<0.05). A positive relationship was identified between CYP1A1 mRNA levels and the presence of chronic disease, alcohol use, tumor size, metastasis and an advanced clinical stage (P<0.05). Conclusions: The results suggest that CYP1A1 gene expression could be used as a marker for thyroid cancer. |
| Colaborador(es) u otros Autores: | Sánchez-Roldán J Ronquillo-Sánchez MD Carmona-Aparicio L Floriano-Sánchez E Cárdenas-Rodríguez N |
| Fecha de publicación : | 2016 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.14456/apjcp.2016.120/APJCP.2016.17.7.3477 |
| Fuente: | Asian Pacific Journal of Cancer Prevention 17(7):3477 - 3482 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2456 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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