1. Instituto Nacional de Pediatría
2. INP
3. Artículos

Título :	Immune sexual dimorphism: effect of gonadal steroids on the expression of cytokines, sex steroid receptors, and lymphocyte proliferation
Creador:	De León Nava MA
Nivel de acceso:	Open access
Palabras clave :	Proliferación de la Célula - efectos de drogas - ratones Citocinas - metabolismo - ratones Regulación de la Expresión Génica - efectos de drogas - ratones Hormonas Esteroides Gonadales - farmacología - ratones Linfocitos - citología - ratones Linfocitos - efectos de drogas - ratones Linfocitos - inmunologia - ratones ARN Mensajero - genética - ratones ARN Mensajero - metabolismo - ratones Receptores de Superficie Celular - genética - ratones Receptores de Superficie Celular - metabolismo - ratones Caracteres Sexuales - ratones Bazo - citología - ratones Bazo - efectos de drogas - ratones Bazo - metabolismo - ratones Células TH1 - citología - ratones Células TH1 - efectos de drogas - ratones Células TH1 - inmunologia - ratones Células TH2 - citología - ratones Células TH2 - efectos de drogas - ratones Células TH2 - inmunologia - ratones Cell Proliferation - drug effects - Mice Cytokines - metabolism - Mice Gene Expression Regulation - drug effects - Mice Gonadal Steroid Hormones - pharmacology - Mice Lymphocytes - cytology - Mice Lymphocytes - drug effects - Mice Lymphocytes - immunology - Mice RNA, Messenger - genetics - Mice RNA, Messenger - metabolism - Mice Receptors, Cell Surface - genetics - Mice Receptors, Cell Surface - metabolism - Mice Sex Characteristics - Mice Spleen - cytology - Mice Spleen - drug effects - Mice Spleen - metabolism - Mice Th1 Cells - cytology - Mice Th1 Cells - drug effects - Mice Th1 Cells - immunology - Mice Th2 Cells - cytology - Mice Th2 Cells - drug effects - Mice Th2 Cells - immunology - Mice Dimorfismo sexual inmune, Receptor de esteroides, Esteroide sexual, Linfocitos, Cytokine, Th1/Th2, Immune sexual dimorphism Steroid receptor Sex steroid Lymphocyte Cytokine Th1/Th2
Descripción :	The aims of this study were, first, to explore the differences in the expression of Th1/Th2 cytokines and of steroid receptors in spleen of intact and gonadectomized mice of both sexes; second, to evaluate the effect of estradiol (E2), progesterone (P4) and testosterone (T) on cytokine production and lymphocyte proliferation, and third, to determine the percentage of spleen cell subpopulations in both sexes. Results indicated dimorphic expression of IFN-gamma and IL-4, which was affected by gonadectomy. CD4+ T lymphocytes were the most frequent type of cell in the spleen, followed by B lymphocytes (CD19+). Interestingly, there was no dimorphic pattern of cell subtypes, and gonadectomy had no effect. Regarding lymphocyte proliferation, E2 inhibited both cells of male (19.51%) and female (24.62%). P4 diminished lymphocyte proliferation by 22% in cells of female and had no effect on cells of male. It is very interesting to note that the sex steroid receptors mRNA was highly expressed in all splenocytes, and that this expression was dimorphic. However, flow cytometry analysis confirmed that only expression of progesterone receptor was dimorphic. This dimorphic pattern was, however, only seen in lymphocytes. Present evidence indicates that sex steroids are capable of affecting crucial immune system functions dimorphically.
Colaborador(es) u otros Autores:	Nava K Soldevila G López-Griego L Chávez-Ríos JR Vargas-Villavicencio JA Morales-Montor J
Fecha de publicación :	2009
Tipo de publicación:	Artículo
Formato:	pdf
Identificador del Recurso :	10.1016/j.jsbmb.2008.11.003
Fuente:	J Steroid Biochem Mol Biol 113(1--2):57-64
URI :	http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2504
Idioma:	eng
Aparece en las colecciones:	Artículos

Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.