Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2507
Título : Immunoglobulin Concentrations in Plasma and Saliva during the Neonatal Period
Creador: Pineda Martínez, Sandra
Nivel de acceso: Open access
Palabras clave : Factores de Edad
Lactancia Materna
Ensayo de Inmunoadsorción Enzimática
Femenino
Humanos
Isotipos de Inmunoglobulinas - metabolismo
Recién nacido
Masculino
Saliva - metabolismo
Age Factors
Breast Feeding
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulin Isotypes - metabolism
Infant, Newborn
Male
Saliva - metabolism
IgA
IgE
IgM
recién nacido
plasma
saliva
IgA
IgE
IgM
newborn
plasma
saliva
Descripción : Background Screening for infectious diseases in newborns using immunoglobulin (Ig)A-, IgM-, and IgE-specific antibodies is expensive and impractical. To determine if total levels of these Igs can be used for screening purposes, thus simplifying the process, their basic levels in the 1st month of extrauterine life need to be determined. Additionally, the ability to simplify screening by using saliva also needs to be determined. The aim of this study was to determine IgA, IgM, and IgE concentrations in plasma and saliva in newborns, correlation between the samples, and relationship between Ig levels and newborn age. Methods We enrolled 53 apparently healthy newborns, paired samples of plasma and saliva were collected, and total IgA, IgM, and IgE concentrations determined by capture enzyme-linked immunosorbent assay. The correlation between plasma and saliva values was calculated by Spearman's rank correlation coefficient and the IgA, IgM, and IgE distributions were analyzed by the Shapiro-Wilk test. We also determined the level of each Ig concentration according to age. Results IgA and IgM levels in plasma and IgA levels in saliva increased significantly during 1st month of life, especially in the 2nd week and 3rd week, with a good correlation of IgA between plasma and saliva. IgE levels in both plasma and saliva and IgM levels in saliva were very low or absent. Conclusion These results suggest that Igs in saliva could be good biomarkers for newborn screening programs during the 1st week of life. This study established reference values for Igs according to age in the neonatal period. © 2015, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license.
Colaborador(es) u otros Autores: Hernandez-Islas José Luis
Escobedo-Torres Mónica Patricia
Paredes-Alonzo Iris Evelin
Lopez-Candiani Carlos
Correa Dolores
Vela-Amieva Marcela
Fecha de publicación : 2016
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1016/j.pedneo.2015.06.005
Fuente: Pediatrics and Neonatology 57(3):213 - 218
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2507
Idioma: eng
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