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Título : Impaired selective cytokine production by CD4+ T cells in Common Variable Immunodeficiency associated with the absence of memory B cells
Creador: Berrón Ruiz, Laura
Nivel de acceso: Open access
Palabras clave : Adulto
Anciano
Antígenos CD274 - genética
Antígenos CD274 - inmunología
Receptor del Factor Activador de Células B - genética
Receptor del Factor Activador de Células B - inmunología
Linfocitos B - inmunología
Linfocitos B - patología
Antígeno CTLA-4 - genética
Antígeno CTLA-4 - inmunología
Proliferación de la Célula
Inmunodeficiencia Variable Común - genética
Inmunodeficiencia Variable Común - inmunología
Inmunodeficiencia Variable Común - patología
Femenino
Humanos
Memoria
Proteína Coestimuladora de Linfocitos T Inducibles - genética
Proteína Coestimuladora de Linfocitos T Inducibles - inmunología
Receptor de Muerte Celular Programada 1 - genética
Receptor de Muerte Celular Programada 1 - inmunología
Linfocitos - inmunología
Linfocitos - patología
Adult
Aged
Antigens, CD274 - genetics
Antigens, CD274 - immunology
B-Cell Activation Factor Receptor/genetics B-Cell Activation Factor Receptor/immunology* B-Lymphocytes/immunology* B-Lymphocytes/pathology CTLA-4 Antigen/genetics CTLA-4 Antigen/immunology Cell Proliferation Common Variable Immunodeficiency/genetics Common Variable Immunodeficiency/immunology* Common Variable Immunodeficiency/pathology Cross-Sectional Studies Female Gene Expression Regulation Humans Immunologic Memory* Inducible T-Cell Co-Stimulator Protein/genetics Inducible T-Cell Co-Stimulator Protein/immunology* Interleukin-10/genetics Interleukin-10/immunology Interleukin-13/genetics Interleukin-13/immunology Interleukin-17/genetics Interleukin-17/immunology Interleukin-9/genetics Interleukin-9/immunology Lymphocyte Activation Lymphocyte Count Male Middle Aged Primary Cell Culture Programmed Cell Death 1 Receptor/genetics Programmed Cell Death 1 Receptor/immunology* Severity of Illness Index Signal Transduction T-Lymphocytes/immunology* T-Lymphocytes/pathology
Activación; La estimulación; Inmunodeficiencia variable común; Citocina; Células de memoria B; Linfocitos T"
Activation; Co-stimulation; Common variable immunodeficiency; Cytokine; Memory B cells; T helper cells
Descripción : Common Variable Immunodeficiency (CVID) is a primary immunodeficiency characterized by B cell dysfunction and decreased serum immunoglobulin. CVID patients are classified by the absence or presence of memory B cells. In addition, T cell defects have been demonstrated in only a proportion of CVID patients. The aim of this study was to evaluate the function of CD4+ T cells from CVID patients and its association with memory B cells. Patients were classified according to their Freiburg groups: group Ia and Ib, with decreased switched memory B cells (<0.4 of PBL), and group II, with normal B cell subsets. Their T cell function was evaluated after stimulation. We observed normal and even increased CD4+ T cell proliferation in group Ia (p = 0.0277). The proliferation positively correlated with the clinical severity score (r = 0.4796). We observed lower levels of IL-17A and IL-10 in group Ia (p = 0.0177, 0.0109) and Ib (p = 0.0009, 0.0084) patients. Group Ib patients also had low levels of IL-13 and IL-9 (p = 0.0169, 0.010). Group II patients had similar cytokine production to that of the controls. BAFFR expression was reduced in groups Ia (p = 0.0001) and Ib (p = 0.0002) and showed an inverse correlation with the severity score (p = 0.0262; r = 0.5371). ICOS expression was reduced in group Ia (p = 0.0364), and PD-1 was increased in group Ib (p = 0.0432) patients. This study shows a selective impairment in cytokine production in group Ia patients, which was more extensive than in group Ib patients. The impairment was associated with BAFFR expression in B cells, with ICOS and PD-1 in T cells and, remarkably, with the absence of memory B cells and with the disease severity. Our results suggest that the evaluation of cytokine expression by T cells in combination with the study of B cell memory could be important for understand the pathogenesis of CVID patients. © 2016 Elsevier Inc.
Colaborador(es) u otros Autores: López-Herrera Gabriela
Vargas-Hernández Alexander
Santos-Argumedo Leopoldo
López-Macías Constantino
Isibasi Armando
Segura-Méndez Nora Hilda
Bonifaz Laura
Fecha de publicación : 2016
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1016/j.clim.2016.03.013
Fuente: Clinical Immunology 166-167():19 - 26
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2515
Idioma: eng
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