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Título : In vitro antimicrobial susceptibility in clinical isolates of Enterococcus species
Creador: Calderón Jaimes E
Nivel de acceso: Open access
Palabras clave : Antibacterianos - farmacología
Enterococcus - efectos de drogas
Enterococcus - aislamiento y purificación
Técnicas In Vitro
Pruebas de Sensibilidad Microbiana - estadísticas y datos numéricos
Anti-Bacterial Agents - pharmacology
Enterococcus - drug effects
Enterococcus - isolation & purification
In Vitro Techniques
Microbial Sensitivity Tests - statistics & numerical data
resistencia microbiana a las drogas
infecciones por enterobacteriaceae
México
drug resistance
microbial
enterobacteriaceae infections
Mexico
Descripción : Objective. To describe the antimicrobial activity of several antimicrobial agents against 97 clinical significant isolates of Enterococcus spp. Material and Methods. During a 2-year prospective study at Instituto Nacional de Pediatria (National Institute of Pediatrics) in Mexico City. Ninety seven strains of Enterococcus spp. (60 E. faecalis and 37 E. faecium) were tested against II antibiotics. Susceptibility tests were performed with agar, according to the standards of the sNational Committee for Clinical Laboratory Standards (NCCLS). Isolates were screened for high-level resistance (HLR) to β-lactams, aminoglycosides, glycopeptides and other antibiotics, as well as for vancomycin-phenotypes. Differences between proportions were evaluated with X2 of Fisher exact fest. Results. Overall resistance rates to the antibiotics tested were: 17/97 (17.5%) to penicillin, ampicillin, amoxicillin-clavulanate and imipenem. There was neither HLR nor β-lactamase production; 74/97 (48.4%) were resistant to erythromycin; 60% to ciprofloxacin; 31/97 (32%) to gentamicin, and 55/97 (56.7%) to streptomycin. Seven strains were vancomycin-resistant enterococci (VRE), all of them identified as E. faecium; 5/7 with Van A and 2/7 with Van B phenotypes. All the isolates were susceptible to linezolid. The difference in susceptibility among species was significant. Conclusions. Mutidrug-resistant enterococci is a real problem and continuous surveillance is necessary. The microbiology laboratory is the first line of defense against the spread of multiantibiotic-resistan enterococci in the hospital environment. All the strains recovered should be tested for susceptibility to ampicillin, streptomycin, gentamicin and glycopeptides.
Colaborador(es) u otros Autores: Arredondo García JL
Aguilar Ituarte F
García Roca P
Fecha de publicación : 2003
Tipo de publicación: Artículo
Formato: pdf
Fuente: Salud Pública de México 45(2):96 - 101
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2521
Idioma: eng
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