Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2527
Título : Increased cytogenetic damage in a zone in transition from agricultural to industrial use:  Comprehensiveanalysis of the micronucleus test in peripheral blood lymphocytes
Creador: Montero R
Nivel de acceso: Open access
Palabras clave : Aberraciones Cromosómicas - inducido químicamente
Daño del ADN Glutatión Transferasa - genética
humanos
industria
Linfocitos - sangre
Micronúcleos con Defecto Cromosómico - inducido químicamente
Pruebas de Micronúcleos - métodos
Exposición Profesional - efectos adversos
Chromosome Aberrations - chemically induced
DNA Damage
Glutathione Transferase - genetics
Lymphocytes - blood
Micronuclei, Chromosome-Defective - chemically induced
Micronucleus Tests - methods
Occupational Exposure - adverse effects
Descripción : A complex situation of chemical exposure has been described in México in a zone that is in transition from rural activities towards intensive industrialization, which has brought environmental pollution: chloroform, methylene chloride, indigo and toluene are some of the pollutants found in the Atoyac and Xochiac rivers. A biomonitoring study was planned in order to establish whether there was a biological effect due to the environmental situation. Communities where leukaemia and thrombocytopenic purpura cases have been reported were included in the study, as well as other communities where such cases have not been described. Three occupations were distinguished, according to chemical exposure: industrial workers, agricultural workers and workers in households, education and commerce. A comprehensive analysis in the micronucleus (MN) test was used to study genotoxicity biomarkers. Two metabolic polymorphisms were determined, namely, glutathione transferase mu1 (GSTM1) and theta1 (GSTT1), which are relevant when oxidative responses are involved. Increased genotoxic damage was found, including cells with >1 MN, >1 chromatin bud, and nucleoplasmic bridges. The genotoxic damage was differentially distributed in the regions studied, being more affected those that are closer to the Atoyac and Xochiac rivers, indicating an effect due to environmental exposure to the contaminants present in the rivers. Further characterization of the exposure regimes in these communities will be done in order to contribute to the alleviation of the health risks that environmental pollution is posing on the inhabitants of this area
Colaborador(es) u otros Autores: Serrano L
Araujo A
Dávila V
Ponce J
Camacho R
Morales E
Mendez A
Fecha de publicación : 2006
Tipo de publicación: Artículo
Formato: PDF
Identificador del Recurso : 10.1093/mutage/gel040
Fuente: Mutagenesis 21(5):335-342
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2527
Idioma: eng
Aparece en las colecciones: Artículos

Ficheros en este ítem:
No hay ficheros asociados a este ítem.


Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.