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Título : Is Toxoplasma gondii type related to clinical outcome in human congenital infection? Systematic and critical review
Creador: Rico Torres Claudia, Patricia
Nivel de acceso: Open access
Palabras clave : Adulto
Femenino
Genotipo
Edad Gestacional
Humanos
Recién nacido
Oportunidad Relativa
Evaluación del Resultado de la Atención al Paciente
Embarazo
Resultado del Embarazo
Toxoplasma - clasificación
Toxoplasma - genética
Toxoplasmosis Congénita - epidemiología
Toxoplasmosis Congénita - parasitología
Toxoplasmosis Congénita - transmisión
Adult
Female
Genotype
Gestational Age
Humans
Infant, Newborn
Odds Ratio
Patient Outcome Assessment
Pregnancy
Pregnancy Outcome
Toxoplasma - classification
Toxoplasma - genetics
Toxoplasmosis, Congenital - epidemiology
Toxoplasmosis, Congenital - parasitology
Toxoplasmosis, Congenital - transmission
Toxoplasmosis, Prenatal, Genotipos, embarazo, Toxoplasma gondii
Toxoplasmosis, Congenital, Genotype, Pregnancy, Toxoplasma
Descripción : In human congenital toxoplasmosis the effects of parasite burden and pregnancy time at infection on clinical outcome are well known, but there is controversy regarding the role of Toxoplasma gondii type. Through a systematic review of the literature, we aimed to discern if T. gondii type has a role on clinical outcome in human congenital toxoplasmosis. We built up a database of congenital toxoplasmosis from reports of cases, case series and screening-based cohorts, which had information about parasite type, gestation time at maternal infection and/or clinical outcome in the product. Then, we obtained frequencies for loci used to genotype geographical origin of cases and types found. Also, odds ratios were calculated for association between time of maternal infection or parasite type on outcome. Type II parasites were the most common in Europe, Asia and Africa, while in America there were mainly atypical strains. More newborns with clinical problems were born from mothers infected during the first half of gestation than from those acquiring the parasite after week 24, regardless of parasite genotype (92.9 vs. 16.1 %, OR = 67.9, CI95 25.4–181.6). Type I and atypical parasites were associated with clinical problems as opposed to types II and III, regardless of pregnancy period at infection (86.9 vs. 72.9 %, OR = 2.47, CI95 1.1–5.4). A significant and remarkable tendency of type I parasites to be present during early pregnancy was also observed (94.4 vs. 5.6 %, P < 0.009). In addition to parasite burden and period of gestation, T. gondii genotype seems involved in CT clinical outcome. © 2016, Springer-Verlag Berlin Heidelberg.
Colaborador(es) u otros Autores: Vargas-Villavicencio José Antonio
Correa Beltran María Dolores
Fecha de publicación : 2016
Tipo de publicación: Revisión
Formato: pdf
Identificador del Recurso : 10.1007/s10096-016-2656-2
Fuente: European Journal of Clinical Microbiology and Infectious Diseases 35(7):1079 - 1088
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2557
Idioma: eng
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