Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2579
Título : Local and Circulating Microchimerism Is Associated Local and Circulating Microchimerism Is Associated with Hypersensitivity Pneumonitis
Creador: Bustos, Martha L.
Nivel de acceso: Open access
Palabras clave : Alveolitis Alérgica Extrínseca - genética
Alveolitis Alérgica Extrínseca - Inmunología
4.- Líquido del Lavado Bronquioalveolar - citología
Proteínas de Ciclo Celular - genética
Quimera - Inmunología
Quimerismo
Mujer
Pulmón - citología
Mediana Edad
Fibrosis Pulmonar - genética
Alveolitis, Extrinsic Allergic - genetics
Alveolitis, Extrinsic Allergic - immunology
Bronchoalveolar Lavage Fluid - cytology
Cell Cycle Proteins - genetics
Chimera - immunology
Chimerism
Lung - cytology
Male
Middle Aged
Pulmonary Fibrosis - genetics
alveolitis alérgica extrínseca
neumonitis de la hipersensibilidad
microquimerismo
allergic extrinsic alveolitis
hypersensitivity pneumonitis
microchimerism
Descripción : Rationale: Hypersensitivity pneumonitis (HP) is a lymphocytic alveolitis provoked by exposure to a variety of antigens. However, the disease occurs in only a subset of exposed individuals, suggesting that additional factors may be involved. Microchimerism has been implicated in the pathogenesis of autoimmune diseases, especially in those showing increased incidence after childbearing age. Objectives: To evaluate the presence of circulating and local microchimeric cells in female patients with HP. Methods: Male microchimerism was examined in 103 patients with HP, 30 with idiopathic pulmonary fibrosis (IPF), and 43 healthy women. All of them had given birth to at least one son, with no twin siblings, blood transfusions, or transplants. Microchimerism was examined by dot blot hybridization (peripheral blood), and by fluorescence in situ hybridization in bronchoalveolar lavage cells and lungs.
Colaborador(es) u otros Autores: Sara Frías
Sandra Ramos
Andrea Estrada
José Luis Arreola
Felipe Mendoza
Miguel Gaxiola
Mauricio Salcedo
Annie Pardo
Moisés Selman
Fecha de publicación : 2007
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1164/rccm.200608-1129OC
Fuente: Am J Resp Crit Care 176(1):90-95
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2579
Idioma: eng
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