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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2600| Título : | Mild Thyroid Hormone Insufficiency During Development Compromises Activity-Dependent Neuroplasticity in the Hippocampus of Adult Male Rats |
| Creador: | ME, Gilbert |
| Nivel de acceso: | Open access |
| Palabras clave : | Animales Antitiroideos - toxicidad Conducta Animal - efectos de drogas Conducta Animal - fisiología Factor Neurotrófico Derivado del Encéfalo - efectos de drogas Factor Neurotrófico Derivado del Encéfalo - genética Factor Neurotrófico Derivado del Encéfalo - metabolismo Condicionamiento (Psicología) - efectos de drogas Condicionamiento (psicología) - fisiología Hipotiroidismo Congénito - inducido químicamente Hipotiroidismo Congénito - embriología Hipotiroidismo Congénito - metabolismo Femenino Hipocampo - embriología Hipocampo - Metabolismo Factores de Transcripción de Tipo Kruppel - efectos de drogas Factores de Transcripción de Tipo Kruppel - genética Transcripción de Tipo Kruppel - metabolismo Hombre Factor de Crecimiento Nervioso - Efectos de drogas Factor de Crecimiento Nervioso - genética Factor de Crecimiento Nervioso - metabolismo Nerve Tissue Proteins - Efectos de drogas Nerve Tissue Proteins - genética Nerve Tissue Proteins - metabolismo Plasticidad Neuronal - Efectos de drogas Plasticidad Neuronal - fisiología Efectos Tardíos de la Exposición Prenatal - inducido químicamente Efectos Tardíos de la Exposición Prenatal - metabolismo Ratas Ratas Long-Evans Triyodotironina - deficiencia Triyodotironina - efectos de drogas Triyodotironina -metabolismo Animals Antithyroid Agents - toxicity Behavior, Animal - drug effects Behavior, Animal - physiology Brain-Derived Neurotrophic Factor - drug effects Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Conditioning (Psychology) - drug effects Conditioning (Psychology) - physiology Congenital Hypothyroidism - chemically induced Congenital Hypothyroidism - embryology Congenital Hypothyroidism - metabolism Female Hippocampus- embryology Hippocampus - metabolism Kruppel-Like Transcription Factors - drug effects Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Male Nerve Growth Factor - drug effects Nerve Growth Factor - genetics Nerve Growth Factor - metabolism Nerve Tissue Proteins - drug effects Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neuronal Plasticity - drug effects Neuronal Plasticity - physiology Pregnancy Prenatal Exposure Delayed Effects - chemically induced Prenatal Exposure Delayed Effects - metabolism Rats Rats, Long-Evans Triiodothyronine - deficiency Triiodothyronine - drug effects Triiodothyronine - metabolism Agentes Antitiroideos, Hormonas Tiroideas, Neuroplasticidad, Hipocampo, Cerebro, Factor Neurotrófico Derivado del Encéfalo Antithyroid Agents, Thyroid Hormones, Neuroplasticity, Hippocampus, Brain, Brain-Derived Neurotrophic Factor |
| Descripción : | Severe thyroid hormone (TH) deficiency during critical phases of brain development results in irreversible neurological and cognitive impairments. The mechanisms accounting for this are likely multifactorial, and are not fully understood. Here we pursue the possibility that one important element is that TH affects basal and activity-dependent neurotrophin expression in brain regions important for neural processing. Graded exposure to propylthiouracil (PTU) during development produced dose-dependent reductions in mRNA expression of nerve growth factor (Ngf) in whole hippocampus of neonates. These changes in basal expression persisted to adulthood despite the return to euthyroid conditions in blood. In contrast to small PTU-induced reductions in basal expression of several genes, developmental PTU treatment dramatically reduced the activity-dependent expression of neurotrophins and related genes (Bdnft, Bdnfiv, Arc, and Klf9) in adulthood and was accompanied by deficits in hippocampal-based learning. These data demonstrate that mild TH insufficiency during development not only reduces expression of important neurotrophins that persists into adulthood but also severely restricts the activity-dependent induction of these genes. Considering the importance of these neurotrophins for sculpting the structural and functional synaptic architecture in the developing and the mature brain, it is likely that TH-mediated deficits in these plasticity mechanisms contribute to the cognitive deficiencies that accompany developmental TH compromise. |
| Colaborador(es) u otros Autores: | Sanchez-Huerta K Wood C. |
| Fecha de publicación : | 2016 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1210/en.2015-1643 |
| Fuente: | Endocrinology 157(2):774-787 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2600 |
| Idioma: | spa |
| Aparece en las colecciones: | Artículos |
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