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Título : Acute infection of Toxoplasma gondii and cytomegalovirus reactivation in a pediatric patient receiving liver transplant
Creador: Galvan Ramirez, M.L.
Nivel de acceso: Open access
Palabras clave : Antivirales - uso terapéutico - niño
Citomegalovirus - aislamiento y purificación - niño
Infecciones por Citomegalovirus - quimioterapia - niño
Infecciones por citomegalovirus - parasitología - niño
Infecciones por citomegalovirus - virología - niño
Ganciclovir - uso terapéutico - niño
trasplante de hígado - métodos - niño
Complicaciones Posoperatorias - parasitología - niño
Complicaciones Posoperatorias - virología - niño
Toxoplasma - aislamiento y purificación - niño
Toxoplasmosis - parasitología - niño
Toxoplasmosis - virología - niño
Retina -lesiones - niño
Antiviral Agents - therapeutic use - child
Cytomegalovirus - isolation & purification - child
Cytomegalovirus Infections - drug therapy - child
Cytomegalovirus Infections -parasitology - child
Cytomegalovirus Infections - virology - child
Ganciclovir - therapeutic use - child
Liver Transplantation - methods - child
Postoperative Complications - parasitology - child
Postoperative Complications virology .- child
Toxoplasma - isolation & purification - child
Toxoplasmosis - parasitology - child
Toxoplasmosis - virology - child
Retina - injuries - child
Citomegalovirus
trasplante de hígado
Toxoplasma gondii
Cytomegalovirus
liver transplantation
Toxoplasma gondii
Descripción : A 7-year-old Mexican boy with end-stage cirrhosis underwent liver transplantation and was maintained with cyclosporine and prednisolone. No specific data about Toxoplasma gondii or cytomegalovirus (CMV) infections in the cadaver donor were available. The recipient was seronegative for Toxoplasma, but CMV-IgG positive before transplantation. Ganciclovir was administered for prophylaxis during 3 months, but 5 months later he presented with icterus and increased transaminases. Acute transplant rejection was ruled out by biopsy. A seroconversion for T. gondii IgM and IgG and a small increase in CMV-IgM antibodies were observed, although the CMV-polymerase chain reaction (PCR) was negative. Ganciclovir was re-started, and the patient improved, but 6 months later he relapsed, and chorioretinitis lesions compatible both with T. gondii and CMV infections appeared. Pyrimethamine, sulfadiazine, folinic acid, and ganciclovir were administered. The boy showed favorable clinical improvement and remained stable for 12 months. Then, new retinal CMV lesions appeared in both eyes and the PCR for CMV became positive; therefore, the patient received a new regimen of ganciclovir, and clinically improved. From these data we concluded that the child presented a reactivation of CMV and a primary infection with T. gondii after transplantion. Copyright © Blackwell Munksgaard 2006.
Colaborador(es) u otros Autores: Castillo-De-Leon Y.
Espinoza-Oliva M.
Bojorques-Ramos M.C.
Rodríguez-Pérez L.R.
Bernal Redondo R.
I. Cañedo-Solares I.
Espinoza López L.
Correa D.
Fecha de publicación : 2006
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1111/j.1399-3062.2006.00140.x
Fuente: Transplant Infectious Disease 8(4):233 - 236
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2620
Idioma: eng
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