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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2633| Título : | Nasal biopsies of children exposed to air pollutants |
| Creador: | Calderón Garcidueñas, Lilian |
| Nivel de acceso: | Open access |
| Palabras clave : | - Contaminantes del aire - efectos adversos Biopsia Niño Exposición por Inhalación - efectos adversos México Mucosa nasal - efectos de drogas Air Pollutants - adverse effects Biopsy Child Inhalation Exposure - adverse effects Mexico Nasal Mucosa - drug effects Contaminantes del aire ambiental niños ozono materia particulada carcinogénesis nasal proteína Air pollutants environmental children ozone particulate matter nasal carcinogenesis protein |
| Descripción : | Southwest Metropolitan Mexico City (SWMMC) atmosphere is a complex mixture of air pollutants, including ozone, particulate matter, and aldehydes. Children in SWMMC are exposed chronically and sequentially to numerous toxicants, and they exhibit signi cant nasal damage. The objective of this study was to assess p53 accumulation by immunohistochemistr y in nasal biopsies of SWMMC children. We evaluated 111 biopsies from 107 children (83 exposed SWMMC children and 24 control children residents in a pollutant-compliant Caribbean island). Complete clinical histories and physical examinations, including an ear–nose–throat (ENT) exam were done. There was a signi cant statistical difference in the upper and lower respiratory symptomatolog y and ENT ndings between control and exposed children (p < 0.001). Control children gave no respiratory symptomatolog y in the 3 months prior to the study; their biopsies exhibited normal ciliated respiratory epithelium and were p53-negative. SWMMC children complained of epistaxis, nasal obstruction, and crusting. Irregular areas of whitish-gray recessed mucosa over the inferior and middle turbinates were seen in 25% of SWMMC children, and their nasal biopsies displayed basal cell hyperplasia, decreased numbers of ciliated and goblet cells, neutrophilic epithelial in ltrates, squamous metaplasia, and mild dysplasia. Four of 21 SWMMC children with grossly abnormal mucosal changes exhibited strong transmural nuclear p53 staining in their nasal biopsies (p 0.005, odds ratio 26). In the context of lifetime exposures to toxic and potentially carcinogenic air pollutants, p53 nasal induction in children could potentially represent. a) a checkpoint response to toxic exposures, setting up a selective condition for p53 mutation, or b) a p53 mutation has already occurred as a result of such selection. Because the biological signi cance of p53 nuclear accumulation in the nasal biopsies of these children is not clear at this point, we strongly suggest that children with macroscopic nasal mucosal abnormalities should be closely monitored by the ENT physician. Parents should be advised to decrease the children’s number of outdoor exposure hours and encourage a balanced diet with an important component of fresh fruits and vegetables |
| Colaborador(es) u otros Autores: | Rodríguez Alacaráz Antonio Valencia Salazar Gildardo Mora Tascareño Antonieta García Raquel Osnaya Norma Villa Real Calderón Anna Devlin Robert B Van Dike Terry |
| Fecha de publicación : | 2001 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1080/019262301317226366 |
| Fuente: | Toxicol Pathol 29(5):558-564 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2633 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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