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Título : Neonatal exposure to monosodium glutamate induces morphological alterations in suprachiasmatic nucleus of adult rat
Creador: Rojas Castañeda, Julio César
Nivel de acceso: Open access
Palabras clave : Animales
Recuento de células
Mujer
Proteína Ácida Fibrilar de la Glía - Metabolismo
masculino
Neuronas - efectos de drogas
Neuronas - metabolismo
Ratas Wistar
Glutamato de Sodio - farmacología
Núcleo Supraquiasmático - efectos de drogas
Núcleo supraquiasmático - crecimiento y desarrollo
Péptido Intestinal Vasoactivo - metabolismo
Vasopresinas - Metabolismo
Animals
Cell Count
Female
Glial Fibrillary Acidic Protein - metabolism
Male
Neurons - drug effects
Neurons - metabolism
Rats, Wistar
Sodium Glutamate - pharmacology
Suprachiasmatic Nucleus - drug effects
Suprachiasmatic Nucleus - growth & development
Vasoactive Intestinal Peptide/metabolism Vasopressins/metabolism
proteína ácida fibrilosa glial; actividad locomotriz; glutamato monosódico; núcleo supraquiasmático; polipéptido intestinal vasoactivo; vasopresina
glial fibrillary acidic protein; locomotor activity; monosodium glutamate; suprachiasmatic nucleus; vasoactive intestinal polypeptide; vasopressin
Descripción : Neonatal exposure to monosodium glutamate (MSG) induces circadian disorders in several physiological and behavioural processes regulated by the suprachiasmatic nucleus (SCN). The objective of this study was to evaluate the effects of neonatal exposure to MSG on locomotor activity, and on morphology, cellular density and expression of proteins, as evaluated by optical density (OD), of vasopressin (VP)-, vasoactive intestinal polypeptide (VIP)- and glial fibrillary acidic protein (GFAP)-immunoreactive cells in the SCN. Male Wistar rats were used: the MSG group was subcutaneously treated from 3 to 10 days of age with 3.5 mg/g/day. Locomotor activity was evaluated at 90 days of age using 'open-field' test, and the brains were processed for immunohistochemical studies. MSG exposure induced a significant decrease in locomotor activity. VP- and VIP-immunoreactive neuronal densities showed a significant decrease, while the somatic OD showed an increase. Major axes and somatic area were significantly increased in VIP neurons. The cellular and optical densities of GFAP-immunoreactive sections of SCN were significantly increased. These results demonstrated that newborn exposure to MSG induced morphological alterations in SCN cells, an alteration that could be the basis for behavioural disorders observed in the animals. International Journal of Experimental Pathology © 2016 International Journal of Experimental Pathology.
Colaborador(es) u otros Autores: Vigueras-Villaseñor Rosa María
Chavez-Saldaña Margarita
Gutierez-Perez Oscar
Rojas Carolina
Arteaga-Silva Marcela
Fecha de publicación : 2016
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1111/iep.12157
Fuente: International Journal of Experimental Pathology 97(1):18 - 26
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2635
Idioma: eng
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