Por favor, use este identificador para citar o enlazar este ítem:
http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2639| Título : | Neonatal caffeine administration causes a permanent increase in the dendritic length of prefrontalcortical neurons of rats |
| Creador: | Juárez Méndez S |
| Nivel de acceso: | Open access |
| Palabras clave : | Animales Recién Nacidos - fisiología Cafeína - farmacología Estimulantes del Sistema Nervioso Central - farmacología Dendritas - efectos de drogas Dendritas - utraestructura Actividad Motora - efectos de drogas Neuronas - efectos de drogas Neuronas - ultraestructura Corteza Prefrontal - citología Corteza Prefrontal - efectos de drogas Corteza Prefrontal - ultraestructura Células Piramidales - fisiología Ratas Sprague-Dawley Animals, Newborn - physiology Caffeine - pharmacology Central Nervous System Stimulants - pharmacology Dendrites - drug effects Dendrites - ultrastructure Motor Activity - drug effects Neurons - drug effects Neurons - ultrastructure Prefrontal Cortex - cytology Prefrontal Cortex - drug effects Prefrontal Cortex - ultrastructure Pyramidal Cells - physiology Rats, Sprague-Dawley Cafeína Neonatal Dendritas Tinción de Golgi-Cox Corteza prefrontal Neuronas piramidales caffeine neonatal dendrites Golgi-Cox stain prefrontal cortex pyramidal neurons |
| Descripción : | We studied the morphological changes of the dendritic length of the pyramidal neurons of the prefrontal cortex (PFC) induced by the effect of chronic administration of caffeine in the neonatal rat. The caffeine (50 mg/kg, s.c.) was injected from day 1 after birth (P1) to day 12 (P12). The morphology of the pyramidal neurons of layer 3 of the PFC was investigated in these animals at two different ages, before puberty (P35) and after puberty (P70). Before the animals were sacrificed by using overdoses of sodium pentobarbital and being perfused intracardially with 0.9% saline, the locomotor activity in a novel environment was measured. The brains were then removed, processed by the Golgi-Cox stain, and analyzed by the Sholl method. The dendritic morphology clearly showed that the neonatal animals administered caffeine showed an increase in the dendritic length of the pyramidal neurons of the PFC when compared with the control animals at both ages. The present results suggest that neonatal administration of caffeine may in part affect the dendritic morphology of the pyramidal cells of this limbic structure and this effect persists after puberty and may be implicated in several brain processes. |
| Colaborador(es) u otros Autores: | Carretero B Martínez-Tellez R Silva-Gómez Ab Flores G |
| Fecha de publicación : | 2006 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1002/syn.20318 |
| Fuente: | Synapse 60(6):450-455 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2639 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.