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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2645| Título : | Neuro-protective effects of carbamazepine on sleep patterns and head and body shakes in kainic acid-treated rats |
| Creador: | Alfaro Rodríguez A |
| Nivel de acceso: | Open access |
| Palabras clave : | Anticonvulsivantes - administración & dosificación - ratas Anticonvulsivantes - farmacologia - ratas Conducta Animal - efectos de drogas - ratas Canales de Calcio Tipo L - metabolismo - ratas Carbamazepina - administración & dosificación - ratas Carbamazepina - farmacologia - ratas Ácido Kaínico - uso terapéutico - ratas Fármacos Neuroprotectores - administración & dosificación - ratas Fármacos Neuroprotectores - farmacologia - ratas Ratas Wistar Convulsiones - inducido químicamente - ratas Convulsiones - quimioterapia - ratas Serotonina - metabolismo - ratas Sueño - efectos de drogas - ratas Anticonvulsants - administration & dosage -rats Anticonvulsants - pharmacology - rats Behavior, Animal - drug effects - rats Calcium Channels, L-Type - metabolism - rats Carbamazepine - administration & dosage - rats Carbamazepine - pharmacology - rats Kainic Acid - therapeutic use - rats Neuroprotective Agents - administration & dosage - rats Neuroprotective Agents - pharmacolog - rats Rats, Wistar Seizures - chemically induced - rats Seizures - drug therapy -rats Serotonin - metabolism - rats Sleep - drug effects - rats Carbamazepine, Ácido kaínico, Dormir, Sacudidas de la cabeza y el cuerpo, 5-HT, rata Carbamazepine Kainic acid Sleep Head and body shakes 5-HT Rat |
| Descripción : | The aim of this work was to analyze the effect of carbamazepine (CBZ) on sleep patterns and on "head and body shakes" and to determine the role of serotonin (5-HT) in a model of kainic-induced seizures. Thirty male Wistar rats (280-300 g) were used for polygraphic sleep recording. After a basal recording, the rats were allocated into three groups: kainic acid-treated animals (KA; 10 mg/kg; n = 10), carbamazepine-treated animals (CBZ; 30 mg/kg; n = 10) and animals injected with KA 30 min after pretreatment with CBZ (CBZ + KA; n = 10). Polygraphic recordings were performed for 10 h for 3 days, with the exception of the CBZ group, which were observed for 1 day. In order to measure the head and body shakes that occurred over that time, a behavioral assessment was performed in two additional groups of KA (n = 10) and CBZ + KA (n = 10) animals. After 10 h of behavioral assessment, the rats were sacrificed, and the levels of 5-HT and 5-hydroxy-indol-acetic acid (5-HIAA) were analyzed. We compared these findings with the results from a group of rats without pharmacological intervention (n = 10). All of the recordings were performed from 08:00 to 18:00 h. Data analysis: the electrographic parameters, head and body shake counting and monoamine concentrations were analyzed by an ANOVA test. Differences of *p ≤ 0.01 and **p ≤ 0.001 were considered statistically significant. Our results showed that CBZ exerted a protective effect on sleep pattern alterations induced by KA, which when administered alone caused a complete inhibition of sleep for the first 10 h after administration. Although there was a reduction in the amount of sleep after the administration of KA in CBZ-pretreated animals, sleep inhibition was incomplete. In addition, CBZ decreased the frequency of head and body shakes by 60% as compared to KA. The 5-HT and 5-HIAA levels in the pons were increased in the KA and KA + CBZ groups. Our conclusion is that in addition to decreasing seizure intensity, CBZ facilitates the partial recovery of sleep. These results suggest that CBZ provides neuro-protective effects on sleep and against seizures. © 2009 Elsevier Ireland Ltd. All rights reserved. |
| Colaborador(es) u otros Autores: | González-Piña R Arch-Tirado E Carrasco-Portugal M Pérez-Guillé B Soriano-Rosales RE Padilla-Martin K Uribe-Escamilla R Labra-Ruiz N |
| Fecha de publicación : | 2009 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1016/j.cbi.2009.04.007 |
| Fuente: | Chemico-Biological Interactions 180(3):376 - 382 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2645 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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