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Título : Oregano (Lippia spp.) kills Giardia intestinalis trophozoites in vitro: Antigiardiasic activity and ultrastructural damage
Creador: Ponce Macotela, Martha
Nivel de acceso: Open access
Palabras clave : Antiprotozoarios - farmacología
Núcleo Celular - ultraestructura
Supervivencia Celular
Giardia lamblia - efectos de drogas
Giardia lamblia - ultraestructura
humanos
Microscopía Electrónica de Transmisión
Origanum - química
Extractos Vegetales - farmacología
Coloración y Etiquetado
Sales de Tetrazolio - metabolismo
Tiazoles - metabolismo
Trofozoítos - efectos de drogas
Antiprotozoal Agents - pharmacology
Cell Nucleus - ultrastructure
Cell Survival
Giardia lamblia - drug effects
Giardia lamblia - ultrastructure
Microscopy, Electron, Transmission Origanum - chemistry
Plant Extracts - pharmacology
Staining and Labeling
Tetrazolium Salts - metabolism
Thiazoles - metabolism
Trophozoites - drug effects
Descripción : In the world, giardiosis is still a very important parasitic disease; only in Asia, Africa and America, there are more than 200 million of infected people in a year. The usual treatments are drugs that produce undesirable secondary effects, perhaps favouring the resistant strain selection. One alternative is to research compounds from plants used as antidiarrhoeic or antiparasitic in the traditional medicine. In a previous work, we found that Lippia beriandieri (Oregano) revealed to be more potent than tinidazole, a common antigiardiasic drug. In this current work, we tested the cell viability by re-culture and reduction of MTT-tetrazolium salts to MTT-formazan, and we showed the effect of oregano ethanolic extracts against Giardia intestinalis (synonyms: Giardia duodenalis, Giardia lamblia) trophozoites at concentrations ranging form 58 to 588 microg. We demonstrated the ultrastructural injury produced by oregano extracts in this parasite. Trophozoites lost their size and shape and showed damage in nucleus structure, perhaps by breaking the pattern of nucleoskeleton proteins
Colaborador(es) u otros Autores: Rufino-Gonzalez Y
Gonzalez-Maciel A
Reynoso-Robles R
Martinez-Gordillo Mn.
Fecha de publicación : 2006
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1007/s00436-005-0082-y
Fuente: Parasitology Research 98(6):557 - 560
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2660
Idioma: eng
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