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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2662| Título : | Overview of Nrf2 as therapeutic target in epilepsy |
| Creador: | Carmona Aparicio, Liliana |
| Nivel de acceso: | Open access |
| Palabras clave : | Animales Epilepsia - tratamiento farmacológico Epilepsia - metabolismo Humanos Terapia Molecular Dirigida - métodos Factor 2 Relacionado con NF-E2 - química Factor 2 Relacionado con NF-E2 - metabolismo Estrés Oxidativo Transducción de Señales Animals Epilepsy - drug therapy Epilepsy - metabolism Humans Molecular Targeted Therapy - methods NF-E2-Related Factor 2 - chemistry NF-E2-Related Factor 2 - metabolism Oxidative Stress Signal Transduction Nrf2 Epilepsia Estrés oxidativo | Factor de transcripción nuclear Nrf2 epilepsy stress oxidative transcription factor nuclear |
| Descripción : | Oxidative stress is a biochemical state of imbalance in the production of reactive oxygen and nitrogen species and antioxidant defenses. It is involved in the physiopathology of degenerative and chronic neuronal disorders, such as epilepsy. Experimental evidence in humans and animals support the involvement of oxidative stress before and after seizures. In the past few years, research has increasingly focused on the molecular pathways of this process, such as that involving transcription factor nuclear factor E2-related factor 2 (Nrf2), which plays a central role in the regulation of antioxidant response elements (ARE) and modulates cellular redox status. The aim of this review is to present experimental evidence on the role of Nrf2 in this neurological disorder and to further determine the therapeutic impact of Nrf2 in epilepsy. © 2015 by the authors; licensee MDPI, Basel, Switzerland. |
| Colaborador(es) u otros Autores: | Pérez-Cruz C Zavala-Tecuapetla C Granados-Rojas L Rivera-Espinosa L Montesinos-Correa H Hernández-Damián J Pedraza-Chaverri J Sampieri A Coballase-Urrutia E Cárdenas-Rodríguez N |
| Fecha de publicación : | 2015 |
| Tipo de publicación: | Revisión |
| Formato: | |
| Identificador del Recurso : | 10.3390/ijms160818348 |
| Fuente: | International Journal of Molecular Sciences 16(8):18348 - 18367 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2662 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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