Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2683
Título : Pharmacokinetics and metabolic rates of acetyl salicylic acid and its metabolites in an Otomi ethnic group of Mexico
Creador: Lares Asseff, Ismael
Nivel de acceso: Open access
Palabras clave : Aspirina - farmacocinetica
Aspirina - metabolismo
Aspirin - phatrmacokinetics
Aspirina - metabolism
Farmacocinética
Metabolismo
Salicilato
Grupo étnico
Otomí
Pharmacokinetics
Metabolism
Salicylate
Ethnic group
Otomi
Descripción : The objective of this study was to determine pharmacokinetic differences of acetyl salicylic acid (ASA) and its metabolites: gentisic acid (GA), salicylic acid (SA) and salicyluric acid (SUA) between Otomies and Mesticians healthy subjects. Design. Ten Otomies and 10 Mesticians were included. After a single dose of aspirin given orally (15 mg/kg), blood and urine samples were collected at different times. Results. Pharmacokinetic parameters of salicylates showed significant differences, except distribution volume of SA, and elimination half-life of SUA. Metabolic rates of ASA showed significant differences for all rates between both groups. On the other hand, percentages of dose excreted were more reduced for SA and SUA for the Otomies than for the Mesticians. Conclusion. Results reflect differences in the hydrolysis way i.e. from ASA to SA and aromatic hydroxylation i.e. from SA to GA, which were slower in Otomies subjects, showing a possible pharmacokinetic differences about the capabilities of ASA biotransformation as a consequence of ethnic differences. © 2004 Pharmaceutical Society of Japan.
Colaborador(es) u otros Autores: Juárez Olguín HUGO
Flores Pérez J
Guillé Pérez A
Vargas A
Fecha de publicación : 2004
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1248/bpb.27.706
Fuente: Biological and Pharmaceutical Bulletin 27(5):706 - 709
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2683
Idioma: eng
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